BDBM50587876 CHEMBL5208108

SMILES [H][C@]12CN(C[C@@H](C)N1Cc1cc(ccc21)N1CC2CNCC2(C1)OC)c1ccc(C#N)c2ncccc12

InChI Key InChIKey=STWJRRQLEOCSIF-LJWPGGNMSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50587876   

TargetToll-like receptor 7(Homo sapiens (Human))
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50587876(CHEMBL5208108)
Affinity DataIC50: <3nMAssay Description:Antagonist activity at R848 stimulated TRL7 in HEK-Blue hTLR7 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetToll-like receptor 9(Homo sapiens (Human))
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50587876(CHEMBL5208108)
Affinity DataIC50: <32nMAssay Description:Antagonist activity at R848 stimulated TRL9 in HEK-Blue hTLR9 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetToll-like receptor 8(Homo sapiens (Human))
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50587876(CHEMBL5208108)
Affinity DataIC50: <3nMAssay Description:Antagonist activity at R848 stimulated TRL8 in HEK-Blue hTLR8 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed