BDBM50588255 CHEMBL5170195

SMILES COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)-c1ccc(CN2CCOCC2)cc1

InChI Key InChIKey=MVDJPUVLCKJATA-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50588255   

TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50588255(CHEMBL5170195)
Affinity DataIC50: <3nMAssay Description:Inhibition of CDK9 (unknown origin) using FITC-X-GSRTPMY-NH2 as substrate preincubated for 10 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50588255(CHEMBL5170195)
Affinity DataIC50:  110nMAssay Description:Inhibition of CDK1 (unknown origin) using 5FAM-RRRFRPASPLRGPPK-COOH as substrate preincubated for 10 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCaspase-3/Caspase-7(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50588255(CHEMBL5170195)
Affinity DataEC50:  140nMAssay Description:Activation of caspase 3/7 in human MV4-11 cells incubated for 6 hrs by Caspase-Glo 3/7 reagent based microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50588255(CHEMBL5170195)
Affinity DataIC50:  16nMAssay Description:Inhibition of CDK9 (unknown origin) using FITC-X-GSRTPMY-NH2 as substrate preincubated for 10 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50588255(CHEMBL5170195)
Affinity DataIC50:  140nMAssay Description:Inhibition of CDK9 in human MCF7 cells assessed as reduction in RNA polymerase II phosphorylation at ser2 residue incubated for 6 hrs by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50588255(CHEMBL5170195)
Affinity DataIC50:  240nMAssay Description:Inhibition of CDK2 (unknown origin) using FL-Ahx-QSPKKG-CONH2 as substrate preincubated for 10 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed