BDBM50588266 CHEMBL5181709

SMILES CC(C)n1c(C)nc2ccc(cc12)-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N(C)C)CC1

InChI Key InChIKey=AHFARWUGWOGTLO-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50588266   

TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50588266(CHEMBL5181709)
Affinity DataIC50:  21nMAssay Description:Inhibition of CDK1 (unknown origin) using 5FAM-RRRFRPASPLRGPPK-COOH as substrate preincubated for 10 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50588266(CHEMBL5181709)
Affinity DataIC50:  84nMAssay Description:Inhibition of CDK2 (unknown origin) using FL-Ahx-QSPKKG-CONH2 as substrate preincubated for 10 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCaspase-3/Caspase-7(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50588266(CHEMBL5181709)
Affinity DataEC50:  57nMAssay Description:Activation of caspase 3/7 in human MV4-11 cells incubated for 6 hrs by Caspase-Glo 3/7 reagent based microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50588266(CHEMBL5181709)
Affinity DataIC50:  13nMAssay Description:Inhibition of CDK9 in human MCF7 cells assessed as reduction in RNA polymerase II phosphorylation at ser2 residue incubated for 6 hrs by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50588266(CHEMBL5181709)
Affinity DataIC50: <3nMAssay Description:Inhibition of CDK9 (unknown origin) using FITC-X-GSRTPMY-NH2 as substrate preincubated for 10 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed