BDBM50592196 CHEMBL5174433

SMILES Cc1ccc(F)c2[nH]c(nc12)-c1cncc(-c2cc(F)cc(c2)C#N)c1N1CC[C@H](N)C1

InChI Key InChIKey=UJNUFHFWKHCQNO-KRWDZBQOSA-N

Data  5 IC50  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50592196   

TargetSomatostatin receptor type 5(Homo sapiens (Human))
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592196(CHEMBL5174433)
Affinity DataEC50:  0.230nMAssay Description:Agonist activity at human SST5 expressed in CHO-K1 cells assessed as reduction in NKH477-induced intracellular cAMP levelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSomatostatin receptor type 5(Homo sapiens (Human))
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592196(CHEMBL5174433)
Affinity DataEC50:  0.251nMAssay Description:Agonist activity at human SST5 expressed in CHO-K1 cells assessed as reduction in NKH477-induced intracellular cAMP levelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSomatostatin receptor type 1(Homo sapiens (Human))
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592196(CHEMBL5174433)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human SST1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSomatostatin receptor type 1(Homo sapiens (Human))
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592196(CHEMBL5174433)
Affinity DataEC50: <1.00E+3nMAssay Description:Agonist activity at human SST1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592196(CHEMBL5174433)
Affinity DataEC50:  251nMAssay Description:Agonist activity at human SST2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSomatostatin receptor type 3(Homo sapiens (Human))
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592196(CHEMBL5174433)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human SST3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592196(CHEMBL5174433)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) preincubated for 30 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSomatostatin receptor type 2(RAT)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592196(CHEMBL5174433)
Affinity DataEC50:  0.316nMAssay Description:Agonist activity at rat SST5More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSomatostatin receptor type 2(RAT)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592196(CHEMBL5174433)
Affinity DataEC50:  0.310nMAssay Description:Agonist activity at rat SST5More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592196(CHEMBL5174433)
Affinity DataIC50:  280nMAssay Description:Inhibition of hERG by patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592196(CHEMBL5174433)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592196(CHEMBL5174433)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin) preincubated for 30 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592196(CHEMBL5174433)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSomatostatin receptor type 4(Homo sapiens (Human))
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592196(CHEMBL5174433)
Affinity DataEC50:  4nMAssay Description:Agonist activity at human SST4More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed