BDBM50598839 CHEMBL5184178

SMILES Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2nc3cc(ccc3nc12)C1=CCCC1

InChI Key InChIKey=RBMXADXPRMLUMH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50598839   

TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598839(CHEMBL5184178)
Affinity DataIC50:  300nMAssay Description:Inhibition of N-terminal recombinant PKMYT1 (76 to 362 residues) in CCNE1 amplified human FU-OV-1 cells assessed as phosphorylation of CDK1 at Thr14 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598839(CHEMBL5184178)
Affinity DataIC50:  5nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed