BDBM50599222 CHEMBL5190644::US11866405, Example 12

SMILES COc1cc2nn(cc2cc1C(=O)Nc1cnc2cccnn12)[C@H]1CC[C@@]2(CCC(=O)N2C)CC1

InChI Key InChIKey=HDVFOUJUARLQJK-QFMRLBMFSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50599222   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50599222(CHEMBL5190644 | US11866405, Example 12)
Affinity DataIC50:  0.100nMAssay Description:The inhibitory activity of compounds against IRAK4 were determined in an enzymatic assay using mass spectrometry readout. Ten point half-log compound...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50599222(CHEMBL5190644 | US11866405, Example 12)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of recombinant human full-length His-tagged IRAK4 expressed in baculovirus infected insect cells using KKARFSRFAGSSPSQSSMVAR as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50599222(CHEMBL5190644 | US11866405, Example 12)
Affinity DataIC50:  1nMAssay Description:The inhibitory activity of compounds against IRAK4 were determined in an enzymatic assay using mass spectrometry readout. Ten point half-log compound...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent