BDBM50600689 CHEMBL5175397
SMILES Nc1nc(N)c2nc(cnc2n1)C(=O)NCc1cccc(c1)C(F)(F)F
InChI Key InChIKey=XJIGBPBDYCDOJG-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50600689
TargetPteridine reductase, putative(Trypanosoma brucei brucei (strain 927/4 GUTat10.1))
Heidelberg Institute For Theoretical Studies (Hits)
Curated by ChEMBL
Heidelberg Institute For Theoretical Studies (Hits)
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant Trypanosoma brucei PTR1 expressed in Escherichia coli BL21 (DE3) cells using H2B as substrate in presence of cytochrome c a...More data for this Ligand-Target Pair
TargetPteridine reductase 1(Leishmania major)
Heidelberg Institute For Theoretical Studies (Hits)
Curated by ChEMBL
Heidelberg Institute For Theoretical Studies (Hits)
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of recombinant Leishmania major PTR1 expressed in Escherichia coli BL21 (DE3) cells using H2B as substrate in presence of cytochrome c and...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Heidelberg Institute For Theoretical Studies (Hits)
Curated by ChEMBL
Heidelberg Institute For Theoretical Studies (Hits)
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human DHFR expressed in Escherichia coli BL21 (DE3) cells using dihydrofolate as substrate in presence of NADPH by spectrop...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Heidelberg Institute For Theoretical Studies (Hits)
Curated by ChEMBL
Heidelberg Institute For Theoretical Studies (Hits)
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant Leishmania major DHFR-TS expressed in Escherichia coli BL21 (DE3) cells using dihydrofolate as substrate in presence of NAD...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei (strain 927/4 GUTat10.1))
Heidelberg Institute For Theoretical Studies (Hits)
Curated by ChEMBL
Heidelberg Institute For Theoretical Studies (Hits)
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant Trypanosoma brucei DHFR-TS expressed in Escherichia coli BL21 (DE3) cells using dihydrofolate as substrate in presence of N...More data for this Ligand-Target Pair