BDBM50605748 CHEMBL5206328

SMILES CC(C)c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)cn12

InChI Key InChIKey=PDQRLXXNHRRHKI-WUFINQPMSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50605748   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50605748(CHEMBL5206328)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human recombinant full length GST-tagged p38alpha expressed in Escherichia coli preincubated for 2 hrs followed by ATP addition and mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase 13(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50605748(CHEMBL5206328)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of recombinant human full length His-tagged p38delta expressed in baculovirus expression system preincubated for 2 hrs followed by ATP add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetMitogen-activated protein kinase 12(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50605748(CHEMBL5206328)
Affinity DataIC50:  164nMAssay Description:Inhibition of recombinant human full length His-tagged p38gamma expressed in baculovirus expression system preincubated for 2 hrs followed by ATP add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50605748(CHEMBL5206328)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of recombinant human full length His-tagged p38beta expressed in baculovirus expression system preincubated for 2 hrs followed by ATP addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed