BDBM510980 1-(2,2-difluoroethyl)-6-(2- hydroxy-2- methylpropoxy)-N-[(4s)-6- ({5-carbamoyl-1-methyl- 1H-pyrazolo[3,4-b]pyridin- 6-yl}oxy)spiro[3.3]heptan- 2-yl]-1H-indazole-3- carboxamide::US11078197, Example 159::US11673886, Example 159

SMILES Cn1ncc2cc(C(N)=O)c(O[C@H]3C[C@@]4(C[C@@H](C4)NC(=O)c4nn(CC(F)F)c5cc(OCC(C)(C)O)ccc45)C3)nc12

InChI Key InChIKey=VRQTZJJHVKGEGX-ZVXFEBSPSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510980   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510980(1-(2,2-difluoroethyl)-6-(2- hydroxy-2- methylpropo...)
Affinity DataIC50:  1.10nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510980(1-(2,2-difluoroethyl)-6-(2- hydroxy-2- methylpropo...)
Affinity DataIC50:  1.10E+3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent