BDBM512913 US11091444, Compound FAH-3::US11142505, FAH #3

SMILES CN1C(N)=NC(C1=O)(c1ccc(OC(F)F)c(C)c1)c1cc(F)cc(F)c1

InChI Key InChIKey=GDKGAYIPAAQPCP-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 512913   

TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Buck Institute For Research On Aging

US Patent
LigandPNGBDBM512913(US11091444, Compound FAH-3 | US11142505, FAH #3)
Affinity DataIC50:  520nMAssay Description:β-sectretase inhibitor IV from Calbiochem (cat #565788).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
The Regents of The University of California

US Patent
LigandPNGBDBM512913(US11091444, Compound FAH-3 | US11142505, FAH #3)
Affinity DataIC50:  710nMAssay Description:Approximately 200 nM to 10 μM substrate, approximately 10 to 200 pM enzyme, and approximately 0.1 nM to 10 μM of the agent(s), in aqueous s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
The Regents of The University of California

US Patent
LigandPNGBDBM512913(US11091444, Compound FAH-3 | US11142505, FAH #3)
Affinity DataIC50:  530nMAssay Description:Approximately 200 nM to 10 μM substrate, approximately 10 to 200 pM enzyme, and approximately 0.1 nM to 10 μM of the agent(s), in aqueous s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Buck Institute For Research On Aging

US Patent
LigandPNGBDBM512913(US11091444, Compound FAH-3 | US11142505, FAH #3)
Affinity DataKd:  300nMAssay Description:β-sectretase inhibitor IV from Calbiochem (cat #565788).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent