BDBM517689 NY0562::US11124489, Compound 33

SMILES FC(F)(F)c1cc(NNC(C#N)C(=O)c2noc3ccccc23)ccc1Cl

InChI Key InChIKey=YFENATLNLYOPJE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 517689   

TargetRap guanine nucleotide exchange factor 4(Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM517689(NY0562 | US11124489, Compound 33)
Affinity DataIC50:  1.90E+3nMAssay Description:From the biological results discussed above, compounds 10, 14-15, 23-24, 26-27, and 31-32 were identified as potent EPAC1 inhibitors with IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM517689(NY0562 | US11124489, Compound 33)
Affinity DataIC50:  2.70E+3nMAssay Description:To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent