BDBM528582 US11192900, Compound 2::US11192900, Example S-9

SMILES CNc1cc(cn(C)c1=O)-c1cc(NC(=O)C#C)ccc1Oc1ccc(F)cc1F

InChI Key InChIKey=KSVUPBCPGPXJMG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 528582   

TargetBromodomain-containing protein 4 [353-454](Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM528582(US11192900, Compound 2 | US11192900, Example S-9)
Affinity DataIC50:  117nMAssay Description:The bromodomain binding assays were performed by Reaction Biology Corp., Malvern, Pa., USA (www.reactionbiology.com). The BET binding assays were con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [58-164](Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM528582(US11192900, Compound 2 | US11192900, Example S-9)
Affinity DataIC50:  52nMAssay Description:The bromodomain binding assays were performed by Reaction Biology Corp., Malvern, Pa., USA (www.reactionbiology.com). The BET binding assays were con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent