BDBM552996 N-(4-fluoro-2-(4- methylpiperazin-1-yl)-5- (2-morpholinopyridin-4- yl)phenyl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3- carboxamide::US11319299, Example 46::US11319299, Example 60

SMILES CN1CCN(CC1)c1cc(F)c(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1ccnc(c1)N1CCOCC1

InChI Key InChIKey=IIHUZGGGNFKXJX-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 552996   

TargetMLL1-WRAD2 complex(Homo sapiens (Human))
Propellon Therapeutics

US Patent
LigandPNGBDBM552996(N-(4-fluoro-2-(4- methylpiperazin-1-yl)-5- (2-morp...)
Affinity DataIC50:  2.29E+3nMAssay Description:Compound potency was assessed through incorporation of 3H-SAM into oligonucleosomes purified from HeLa cells. Specifically, recombinant human MLL1 (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetWD repeat-containing protein 5(Homo sapiens (Human))
Propellon Therapeutics

US Patent
LigandPNGBDBM552996(N-(4-fluoro-2-(4- methylpiperazin-1-yl)-5- (2-morp...)
Affinity DataKd:  4.79nMAssay Description:Exemplary compounds of the application were dissolved in 100% DMSO at 10 mM, assayed fresh, and then stored at −20° C. for repeat studies and o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetWD repeat-containing protein 5(Homo sapiens (Human))
Propellon Therapeutics

US Patent
LigandPNGBDBM552996(N-(4-fluoro-2-(4- methylpiperazin-1-yl)-5- (2-morp...)
Affinity DataKd:  5nMAssay Description:Exemplary compounds of the application were dissolved in 100% DMSO at 10 mM, assayed fresh, and then stored at −20° C. for repeat studies and o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent