BDBM594234 US11584747, Example 28::US11584747, Example 29

SMILES CC[C@@H]1CN([C@@H](CC)CN1C(C)c1ccc(cc1)C1CC1)c1nc(=O)n(C)c2ccc(nc12)C#N

InChI Key InChIKey=JGRVZUUDZWOFMT-CLNKXKAZSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 594234   

TargetDiacylglycerol kinase alpha(Homo sapiens)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594234(US11584747, Example 28 | US11584747, Example 29)
Affinity DataIC50:  1.57E+3nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase zeta(Homo sapiens)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594234(US11584747, Example 28 | US11584747, Example 29)
Affinity DataIC50:  10nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase alpha(Homo sapiens)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594234(US11584747, Example 28 | US11584747, Example 29)
Affinity DataIC50:  40nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase zeta(Homo sapiens)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594234(US11584747, Example 28 | US11584747, Example 29)
Affinity DataIC50:  2.65E+3nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent