BDBM608888 US11702409, Example 27a::US11702409, Example 27b

SMILES Cc1c(c(nn1C1CC2(C1)CN(C2)C(=O)C=C)-c1cccnc1)-c1c(Cl)c(C)cc2[nH]ncc12

InChI Key InChIKey=JHXPVVRDTOITEP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 608888   

TargetGTPase KRas [G12C](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM608888(US11702409, Example 27a | US11702409, Example 27b)
Affinity DataIC50:  251nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM608888(US11702409, Example 27a | US11702409, Example 27b)
Affinity DataIC50:  90nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGTPase KRas [G12C](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM608888(US11702409, Example 27a | US11702409, Example 27b)
Affinity DataIC50:  1.99E+4nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent