BDBM6220 4-[({4-[(5-chloro-2H-1,3-benzodioxol-4-yl)amino]-6-methoxyquinazolin-7-yl}oxy)methyl]pyridine-2-carbonitrile::Chlorobenzodioxole deriv. 29

SMILES COc1cc2c(Nc3c4OCOc4ccc3Cl)ncnc2cc1OCc1ccnc(c1)C#N

InChI Key InChIKey=DLSRIJJGQIAZHW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 6220   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM6220(4-[({4-[(5-chloro-2H-1,3-benzodioxol-4-yl)amino]-6...)
Affinity DataIC50:  7.70E+4nMAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit receptor tyrosine kinase activity. The compounds were incubated with enzym...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM6220(4-[({4-[(5-chloro-2H-1,3-benzodioxol-4-yl)amino]-6...)
Affinity DataIC50: >1.00E+5nMAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit receptor tyrosine kinase activity. The compounds were incubated with enzym...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM6220(4-[({4-[(5-chloro-2H-1,3-benzodioxol-4-yl)amino]-6...)
Affinity DataIC50: >1.00E+5nMAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit receptor tyrosine kinase activity. The compounds were incubated with enzym...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM6220(4-[({4-[(5-chloro-2H-1,3-benzodioxol-4-yl)amino]-6...)
Affinity DataIC50:  10nMT: 2°CAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed