BDBM640277 4-{6-[2-(7-Methoxy-5-methyl-2,3-dihydro-benzo[1,4]dioxin-6-yl)-ethylamino]- pyrimidin-4-yl}-2-methylsulfanyl-benzoic acid::US11839613, Example 400

SMILES COc1cc2OCCOc2c(C)c1CCNc1cc(ncn1)-c1ccc(C(O)=O)c(SC)c1

InChI Key InChIKey=CVMFUYFBWFFWSG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 640277   

TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM640277(4-{6-[2-(7-Methoxy-5-methyl-2,3-dihydro-benzo[1,4]...)
Affinity DataIC50:  37nMAssay Description:The BT549 cells (NCI/No. 0507282) are detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected in growing ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM640277(4-{6-[2-(7-Methoxy-5-methyl-2,3-dihydro-benzo[1,4]...)
Affinity DataIC50:  2nMAssay Description:The SF295 cells (NCI/No. 0503170) are detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected in growing ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent