BDBM7507 2,6,9-Trisubstituted purine deriv. 5c::CHEMBL133533::N-benzyl-2-iodo-9-(propan-2-yl)-9H-purin-6-amine

SMILES CC(C)n1cnc2c(NCc3ccccc3)nc(I)nc12

InChI Key InChIKey=MKMXWDSWLHBSGA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 7507   

TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Institut Curie

LigandPNGBDBM7507(2,6,9-Trisubstituted purine deriv. 5c | CHEMBL1335...)
Affinity DataIC50:  8.00E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Institut Curie

Curated by ChEMBL
LigandPNGBDBM7507(2,6,9-Trisubstituted purine deriv. 5c | CHEMBL1335...)
Affinity DataIC50:  1.30E+4nMAssay Description:Compound was tested for its inhibitory activity against cyclin-dependent kinase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Institut Curie

Curated by ChEMBL
LigandPNGBDBM7507(2,6,9-Trisubstituted purine deriv. 5c | CHEMBL1335...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of Cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Institut Curie

LigandPNGBDBM7507(2,6,9-Trisubstituted purine deriv. 5c | CHEMBL1335...)
Affinity DataIC50:  1.30E+4nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed