BDBM7841 BAY 59-7939 Analog 18::US8822458, 45::US9359341, Rivaroxaban

SMILES Cc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O

InChI Key InChIKey=YWRVKEHHSZEJNV-INIZCTEOSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 7841   

TargetCoagulation factor X(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM7841(BAY 59-7939 Analog 18 | US8822458, 45 | US9359341,...)
Affinity DataIC50:  4.20nMT: 2°CAssay Description:The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM7841(BAY 59-7939 Analog 18 | US8822458, 45 | US9359341,...)
Affinity DataIC50:  4.20nMAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Wanbury

US Patent
LigandPNGBDBM7841(BAY 59-7939 Analog 18 | US8822458, 45 | US9359341,...)
Affinity DataIC50:  1.89E+4nMpH: 7.4 T: 2°CAssay Description:Incubation of phenacetin, diclofenac, dextromethorphan, mephenotoin, albendazole and testosterone with human liver microsomes in the presence of in e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Wanbury

US Patent
LigandPNGBDBM7841(BAY 59-7939 Analog 18 | US8822458, 45 | US9359341,...)
Affinity DataIC50:  1.32E+4nMpH: 7.4 T: 2°CAssay Description:Incubation of phenacetin, diclofenac, dextromethorphan, mephenotoin, albendazole and testosterone with human liver microsomes in the presence of in e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
Wanbury

US Patent
LigandPNGBDBM7841(BAY 59-7939 Analog 18 | US8822458, 45 | US9359341,...)
Affinity DataIC50:  1.67E+4nMpH: 7.4 T: 2°CAssay Description:Incubation of phenacetin, diclofenac, dextromethorphan, mephenotoin, albendazole and testosterone with human liver microsomes in the presence of in e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C19(Homo sapiens (Human))
Wanbury

US Patent
LigandPNGBDBM7841(BAY 59-7939 Analog 18 | US8822458, 45 | US9359341,...)
Affinity DataIC50:  1.32E+4nMpH: 7.4 T: 2°CAssay Description:Incubation of phenacetin, diclofenac, dextromethorphan, mephenotoin, albendazole and testosterone with human liver microsomes in the presence of in e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Wanbury

US Patent
LigandPNGBDBM7841(BAY 59-7939 Analog 18 | US8822458, 45 | US9359341,...)
Affinity DataIC50:  9.70E+3nMpH: 7.4 T: 2°CAssay Description:Incubation of phenacetin, diclofenac, dextromethorphan, mephenotoin, albendazole and testosterone with human liver microsomes in the presence of in e...More data for this Ligand-Target Pair
In DepthDetails US Patent