BDBM81975 4-hydroxyquinoline-2-carboxylic acid::CAS_492-27-3::CHEMBL299155::Kynurenate::NSC_5280455

SMILES OC(=O)c1cc(O)c2ccccc2n1

InChI Key InChIKey=HCZHHEIFKROPDY-UHFFFAOYSA-N

Data  6 KI  2 IC50  7 EC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 81975   

TargetG-protein coupled receptor 35(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM81975(4-hydroxyquinoline-2-carboxylic acid | CAS_492-27-...)
Affinity DataKi:  1.37E+5nMAssay Description:Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysisChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 35(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM81975(4-hydroxyquinoline-2-carboxylic acid | CAS_492-27-...)
Affinity DataEC50:  1.52E+5nMAssay Description:Agonist activity at human GPR35 by DMR assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 35(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM81975(4-hydroxyquinoline-2-carboxylic acid | CAS_492-27-...)
Affinity DataEC50:  3.92E+4nMAssay Description:Agonist activity at human GPR35 expressed in CHO cells assessed as increase in intracellular Ca2+ measured over 20 secs by Aequorin assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed