BDBM8392 CHEMBL408564::N-[5-bromo-6-(furan-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide::pyrazolo[3,4-b]pyridine analogue 34

SMILES Brc1cc2c(NC(=O)C3CC3)n[nH]c2nc1-c1ccco1

InChI Key InChIKey=GVYKLTFFLMMUEN-UHFFFAOYSA-N

Data  7 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 8392   

TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8392(CHEMBL408564 | N-[5-bromo-6-(furan-2-yl)-1H-pyrazo...)
Affinity DataIC50:  7nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8392(CHEMBL408564 | N-[5-bromo-6-(furan-2-yl)-1H-pyrazo...)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM8392(CHEMBL408564 | N-[5-bromo-6-(furan-2-yl)-1H-pyrazo...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM8392(CHEMBL408564 | N-[5-bromo-6-(furan-2-yl)-1H-pyrazo...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8392(CHEMBL408564 | N-[5-bromo-6-(furan-2-yl)-1H-pyrazo...)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant human GSKalphaMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8392(CHEMBL408564 | N-[5-bromo-6-(furan-2-yl)-1H-pyrazo...)
Affinity DataIC50:  7nMAssay Description:Inhibition of GSK3alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM8392(CHEMBL408564 | N-[5-bromo-6-(furan-2-yl)-1H-pyrazo...)
Affinity DataKd:  560nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM8392(CHEMBL408564 | N-[5-bromo-6-(furan-2-yl)-1H-pyrazo...)
Affinity DataKd:  2.12E+3nMAssay Description:Binding affinity to human wild type adenosine A1 receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM8392(CHEMBL408564 | N-[5-bromo-6-(furan-2-yl)-1H-pyrazo...)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed