BDBM8395 CHEMBL101747::N-[5-bromo-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2-(1-ethylpiperidin-4-yl)acetamide::pyrazolo[3,4-b]pyridine analogue 37

SMILES CCN1CCC(CC(=O)Nc2n[nH]c3nc(-c4cccs4)c(Br)cc23)CC1

InChI Key InChIKey=GHOXGYVOJHFBKS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 8395   

TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8395(CHEMBL101747 | N-[5-bromo-6-(thiophen-2-yl)-1H-pyr...)
Affinity DataIC50:  18nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM8395(CHEMBL101747 | N-[5-bromo-6-(thiophen-2-yl)-1H-pyr...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8395(CHEMBL101747 | N-[5-bromo-6-(thiophen-2-yl)-1H-pyr...)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed