BDBM84747 (B) ZD6474::US10155768, Vandetanib::US10183928, Vandetanib::US10202365, Compound Vandetanib::US10227329, Compound Vandetanib::US11046696, Vandetanib::US11279688, Compound Vandetanib::Vandetanib

SMILES CN1CCC(COc2cc3ncnc(Nc4ccc(Br)cc4F)c3cc2C)CC1

InChI Key InChIKey=XCZFQNKLJUWULA-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 84747   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM84747((B) ZD6474 | US10155768, Vandetanib | US10183928, ...)
Affinity DataIC50:  9.20nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM84747((B) ZD6474 | US10155768, Vandetanib | US10183928, ...)
Affinity DataIC50:  4.75E+3nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET (V804L) (i.e., RET with V804L mutation) kinase acti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM84747((B) ZD6474 | US10155768, Vandetanib | US10183928, ...)
Affinity DataIC50:  4.33E+3nMAssay Description:RET (V804M) (i.e., RET with V804M mutation) kinase activity was measured using purified recombinant human RET (V804M) protein purchased from Eurofins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent