BDBM8860 3-{4-[4-amino-6-(3-hydroxypropyl)thieno[2,3-d]pyrimidin-5-yl]phenyl}-1-(3-methylphenyl)urea::CHEMBL198297::KDR Kinase Inhibitor, 4::N-{4-[4-Amino-6-(3-hydroxypropyl)thieno[2,3-d]pyrimid-5-yl]phenyl}-N1-(3-methylphenyl)urea::Thienopyrimidine deriv. 86

SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(CCCO)sc3ncnc(N)c23)c1

InChI Key InChIKey=QFPRMYTURWHCEE-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 8860   

TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8860(3-{4-[4-amino-6-(3-hydroxypropyl)thieno[2,3-d]pyri...)
Affinity DataIC50:  110nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8860(3-{4-[4-amino-6-(3-hydroxypropyl)thieno[2,3-d]pyri...)
Affinity DataIC50:  15nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8860(3-{4-[4-amino-6-(3-hydroxypropyl)thieno[2,3-d]pyri...)
Affinity DataIC50:  26nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8860(3-{4-[4-amino-6-(3-hydroxypropyl)thieno[2,3-d]pyri...)
Affinity DataIC50:  25.7nMAssay Description:Inhibition of cKITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8860(3-{4-[4-amino-6-(3-hydroxypropyl)thieno[2,3-d]pyri...)
Affinity DataIC50:  15nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8860(3-{4-[4-amino-6-(3-hydroxypropyl)thieno[2,3-d]pyri...)
Affinity DataIC50:  110nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8860(3-{4-[4-amino-6-(3-hydroxypropyl)thieno[2,3-d]pyri...)
Affinity DataIC50:  15.1nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8860(3-{4-[4-amino-6-(3-hydroxypropyl)thieno[2,3-d]pyri...)
Affinity DataIC50:  15nMAssay Description:Inhibition assay using KDR.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed