BDBM8935 5-[(6-methoxy-1-methyl-3,4-dihydronaphthalen-2-yl)methyl]-1H-imidazole::BW19::CHEMBL448463::IDHN::dihydronaphthalene derivative

SMILES COc1ccc2C(C)=C(Cc3cnc[nH]3)CCc2c1

InChI Key InChIKey=GEXYIIUWEYUZRJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 8935   

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8935(5-[(6-methoxy-1-methyl-3,4-dihydronaphthalen-2-yl)...)
Affinity DataIC50:  110nMpH: 7.4 T: 2°CAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8935(5-[(6-methoxy-1-methyl-3,4-dihydronaphthalen-2-yl)...)
Affinity DataIC50:  1.60E+3nMAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H]androstenedione during aromatization. After incubation, the rea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8935(5-[(6-methoxy-1-methyl-3,4-dihydronaphthalen-2-yl)...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of human aromatase-mediated conversion of [1beta3H]androstenedione to estrone by liquid scintillation counting in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8935(5-[(6-methoxy-1-methyl-3,4-dihydronaphthalen-2-yl)...)
Affinity DataIC50:  110nMAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8935(5-[(6-methoxy-1-methyl-3,4-dihydronaphthalen-2-yl)...)
Affinity DataIC50:  1.70E+4nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta, 2beta-3H] testosterone or [1beta-3H] androstenedione during aroma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed