BDBM8961 1,2,3,4-tetrahydro-9-acridinamine::1,2,3,4-tetrahydroacridin-9-amine::9-THA::9-amino-1,2,3,4-tetrahydroacridine (THA)::CHEMBL1337960::CHEMBL95::Cognex::Tacrine::Tracine::US8999994, Tacrine::cid_1935::tacrine.HCl

SMILES Nc1c2CCCCc2nc2ccccc12

InChI Key InChIKey=YLJREFDVOIBQDA-UHFFFAOYSA-N

Data  53 KI  752 IC50  4 Kd  3 EC50

PDB links: 7 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 8961   

TargetAcetylcholinesterase(Homo sapiens (Human))
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  500nMAssay Description:Inhibition of human SH-SY5Y cell lysate acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrat...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  131nMAssay Description:Inhibition of rat cortex acetylcholinesterase using acetylthiocholine iodide as substrate incubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human acetylcholinesteraseMore data for this Ligand-Target Pair
TargetCholinesterase(Homo sapiens (Human))
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  95nMAssay Description:Inhibition of human CholinesteraseMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  590nMAssay Description:Inhibition of rat brain Acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazine by spectrophotometric m...More data for this Ligand-Target Pair
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  44nMAssay Description:Inhibition of rat serum butyrylcholinesterase using butyrylthiocholine as substrate in presence of AChE inhibitor BW284C51 by spectrophotometric meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  70nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate pretreated followed by substrate addition and measured after 2 mins by El...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  11nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate pretreated followed by substrate addition and measured after 2 mins by ...More data for this Ligand-Target Pair