Affinity DataIC50: 4nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human NAAA expressed in HEK293 cells after 30 mins by UPLC/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human NAAA expressed in HEK293 cells after 30 mins by UPLC/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human NAAA expressed in HEK293 cells using PAMCA as fluorogenic substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human NAAA expressed in HEK293 cells using PAMCA as fluorogenic substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human NAAA expressed in HEK293 cells using PAMCA as fluorogenic substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant human NAAA expressed in HEK293 cells after 30 mins by UPLC/MS analysisMore data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of human NAAA expressed in HEK293 cells preincubated for 10 mins followed by N-(4-methyl-2-oxo-chromen-7-yl)-hexadecanamide substrate addi...More data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant human NAAA expressed in HEK293 cells using PAMCA as fluorogenic substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant human NAAA expressed in HEK293 cells after 30 mins by UPLC/MS analysisMore data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of human NAAA expressed in HEK293 cells preincubated for 10 mins followed by N-(4-methyl-2-oxo-chromen-7-yl)-hexadecanamide substrate addi...More data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of recombinant human NAAA expressed in HEK293 cells using PAMCA as fluorogenic substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of human NAAA expressed in HEK293 cells preincubated for 10 mins followed by N-(4-methyl-2-oxo-chromen-7-yl)-hexadecanamide substrate addi...More data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of human NAAA expressed in HEK293 cells preincubated for 10 mins followed by N-(4-methyl-2-oxo-chromen-7-yl)-hexadecanamide substrate addi...More data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of recombinant human NAAA expressed in HEK293 cells using PAMCA as fluorogenic substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibition of human NAAA expressed in HEK293 cells preincubated for 10 mins followed by N-(4-methyl-2-oxo-chromen-7-yl)-hexadecanamide substrate addi...More data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of recombinant human NAAA expressed in HEK293 cells after 30 mins by UPLC/MS analysisMore data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 49nMAssay Description:Inhibition of human NAAA expressed in HEK293 cells preincubated for 10 mins followed by N-(4-methyl-2-oxo-chromen-7-yl)-hexadecanamide substrate addi...More data for this Ligand-Target Pair
Affinity DataIC50: 49nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 51nMAssay Description:Inhibition of recombinant human NAAA expressed in HEK293 cells using PAMCA as fluorogenic substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 52nMAssay Description:Inhibition of human NAAA expressed in HEK293 cells preincubated for 10 mins followed by N-(4-methyl-2-oxo-chromen-7-yl)-hexadecanamide substrate addi...More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 65nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 71nMAssay Description:Inhibition of human NAAA expressed in HEK293 cells preincubated for 10 mins followed by N-(4-methyl-2-oxo-chromen-7-yl)-hexadecanamide substrate addi...More data for this Ligand-Target Pair
Affinity DataIC50: 71nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 73nMAssay Description:Inhibition of GST-tagged human BRD4 bromodomain1 using H4KAc 5/8/12/16 peptide as substrate incubated overnight by HTRF assayMore data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 73nMAssay Description:Inhibition of human NAAA expressed in HEK293 cells preincubated for 10 mins followed by N-(4-methyl-2-oxo-chromen-7-yl)-hexadecanamide substrate addi...More data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 76nMAssay Description:Inhibition of recombinant human NAAA expressed in HEK293 cells after 30 mins by UPLC/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 77nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 85nMAssay Description:Binding affinity to his-tagged human BRD4 bromodomain1 by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Italian Institute Of Technology
Curated by ChEMBL
Italian Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 93nMAssay Description:Inhibition of recombinant human NAAA expressed in HEK293 cells using PAMCA as fluorogenic substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
Affinity DataIC50: 98nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair