Affinity DataKi: 1.5nM ΔG°: -52.4kJ/molepH: 5.6 T: 2°CAssay Description:Inhibition of HIV-protease activity for selected acids at P3-P3' positions. More data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Compound was tested for inhibitory activity against alpha-1,2-Fucosidase obtained from Arthrobacter oxidans F1More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
The Scripps Research Institute
The Scripps Research Institute
Affinity DataKi: 1.70nM IC50: 6nMAssay Description:The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show...More data for this Ligand-Target Pair
Affinity DataKi: 2nM ΔG°: -51.6kJ/molepH: 5.6 T: 2°CAssay Description:Inhibition of HIV-protease activity for selected acids at P3-P3' positions. More data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataKi: 2.70nMAssay Description:Inhibition of wild type HIV1 proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
The Scripps Research Institute
The Scripps Research Institute
Affinity DataKi: 4nM IC50: 13nMAssay Description:The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica
Academia Sinica
Affinity DataKi: 7.5nMpH: 7.5Assay Description:Inhibition assay against SARS-CoV 3CL protease, a fluorometric assay was utilized to determine the inhibition constants of the samples.More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine kidneyMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
The Scripps Research Institute
The Scripps Research Institute
Affinity DataKi: 9.70nM IC50: 17nMAssay Description:The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
The Scripps Research Institute
The Scripps Research Institute
Affinity DataKi: 10nM IC50: 19nMAssay Description:The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show...More data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Compound was tested for inhibitory activity against alpha-1,2-Fucosidase obtained from Arthrobacter oxidans F1More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica
Academia Sinica
Affinity DataKi: 11.1nMpH: 7.5Assay Description:Inhibition assay against SARS-CoV 3CL protease, a fluorometric assay was utilized to determine the inhibition constants of the samples.More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica
Academia Sinica
Affinity DataKi: 12.1nMpH: 7.5Assay Description:Inhibition assay against SARS-CoV 3CL protease, a fluorometric assay was utilized to determine the inhibition constants of the samples.More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica
Academia Sinica
Affinity DataKi: 12.3nMpH: 7.5Assay Description:Inhibition assay against SARS-CoV 3CL protease, a fluorometric assay was utilized to determine the inhibition constants of the samples.More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
The Scripps Research Institute
The Scripps Research Institute
Affinity DataKi: 13nM IC50: 24nMAssay Description:The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica
Academia Sinica
Affinity DataKi: 13.8nMpH: 7.5Assay Description:Inhibition assay against SARS-CoV 3CL protease, a fluorometric assay was utilized to determine the inhibition constants of the samples.More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica
Academia Sinica
Affinity DataKi: 17.4nMpH: 7.5Assay Description:Inhibition assay against SARS-CoV 3CL protease, a fluorometric assay was utilized to determine the inhibition constants of the samples.More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataKi: 18nMAssay Description:Antagonist activity at human S1P1 receptor expressed in CHO cells assessed as inhibition of SEW2871-induced [35S]GTPgamma bindingMore data for this Ligand-Target Pair
Affinity DataKi: 18nMAssay Description:Ability to inhibit amidase activity of LTA4 hydrolase (1.4 ug) purified from human leukocytesMore data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine epididymisMore data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica
Academia Sinica
Affinity DataKi: 19.5nMpH: 7.5Assay Description:Inhibition assay against SARS-CoV 3CL protease, a fluorometric assay was utilized to determine the inhibition constants of the samples.More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
The Scripps Research Institute
The Scripps Research Institute
Affinity DataKi: 22nM IC50: 39nMAssay Description:The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica
Academia Sinica
Affinity DataKi: 22.9nMpH: 7.5Assay Description:Inhibition assay against SARS-CoV 3CL protease, a fluorometric assay was utilized to determine the inhibition constants of the samples.More data for this Ligand-Target Pair
Affinity DataKi: 24nMAssay Description:Hexosaminidase activity assay was measured by fluorometry, VersaFluor Fluorometer from Bio-Rad.More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
The Scripps Research Institute
The Scripps Research Institute
Affinity DataKi: 27nM IC50: 46nMAssay Description:The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
The Scripps Research Institute
The Scripps Research Institute
Affinity DataKi: 30nM IC50: 52nMAssay Description:The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica
Academia Sinica
Affinity DataKi: 30nM ΔG°: -42.9kJ/mole IC50: 60nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Compound was tested for inhibitory activity against alpha-1,2-Fucosidase obtained from Arthrobacter oxidans F1More data for this Ligand-Target Pair
Affinity DataKi: 37nMAssay Description:IC50 values were determined with serial dilutions (from 100 to 0.1 uM) of inhibitors by a spectrophotometric assay with DTNB, lipoamide, and NADH or ...More data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:Hexosaminidase activity assay was measured by fluorometry, VersaFluor Fluorometer from Bio-Rad.More data for this Ligand-Target Pair
Affinity DataKi: 46nMAssay Description:Ability to inhibit amidase activity of LTA4 hydrolase (1.4 ug) purified from human leukocytesMore data for this Ligand-Target Pair
Affinity DataKi: 47nMAssay Description:Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine kidneyMore data for this Ligand-Target Pair
Affinity DataKi: 65nMAssay Description:Hexosaminidase activity assay was measured by fluorometry, VersaFluor Fluorometer from Bio-Rad.More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataKi: 77nMAssay Description:Antagonist activity at human S1P1 receptor expressed in CHO cells assessed as inhibition of S1P-induced [35S]GTPgamma bindingMore data for this Ligand-Target Pair
Affinity DataKi: 78nMAssay Description:IC50 values were determined with serial dilutions (from 100 to 0.1 uM) of inhibitors by a spectrophotometric assay with DTNB, lipoamide, and NADH or ...More data for this Ligand-Target Pair
Affinity DataKi: 93nMAssay Description:IC50 values were determined with serial dilutions (from 100 to 0.1 uM) of inhibitors by a spectrophotometric assay with DTNB, lipoamide, and NADH or ...More data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Hexosaminidase activity assay was measured by fluorometry, VersaFluor Fluorometer from Bio-Rad.More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
Scripps Research Institute
Curated by ChEMBL
Scripps Research Institute
Curated by ChEMBL
Affinity DataKi: 100nMAssay Description:Inhibition constant was determined against epoxide hydrolaseMore data for this Ligand-Target Pair
Affinity DataKi: 140nMAssay Description:IC50 values were determined with serial dilutions (from 100 to 0.1 uM) of inhibitors by a spectrophotometric assay with DTNB, lipoamide, and NADH or ...More data for this Ligand-Target Pair
Affinity DataKi: 143nMAssay Description:IC50 values were determined with serial dilutions (from 100 to 0.1 uM) of inhibitors by a spectrophotometric assay with DTNB, lipoamide, and NADH or ...More data for this Ligand-Target Pair
Affinity DataKi: 155nMAssay Description:IC50 values were determined with serial dilutions (from 100 to 0.1 uM) of inhibitors by a spectrophotometric assay with DTNB, lipoamide, and NADH or ...More data for this Ligand-Target Pair
Affinity DataKi: 155nMAssay Description:IC50 values were determined with serial dilutions (from 100 to 0.1 uM) of inhibitors by a spectrophotometric assay with DTNB, lipoamide, and NADH or ...More data for this Ligand-Target Pair
Affinity DataKi: 233nMAssay Description:IC50 values were determined with serial dilutions (from 100 to 0.1 uM) of inhibitors by a spectrophotometric assay with DTNB, lipoamide, and NADH or ...More data for this Ligand-Target Pair
Affinity DataKi: 240nMAssay Description:Hexosaminidase activity assay was measured by fluorometry, VersaFluor Fluorometer from Bio-Rad.More data for this Ligand-Target Pair
Affinity DataKi: 289nMAssay Description:IC50 values were determined with serial dilutions (from 100 to 0.1 uM) of inhibitors by a spectrophotometric assay with DTNB, lipoamide, and NADH or ...More data for this Ligand-Target Pair
Affinity DataKi: 333nMAssay Description:IC50 values were determined with serial dilutions (from 100 to 0.1 uM) of inhibitors by a spectrophotometric assay with DTNB, lipoamide, and NADH or ...More data for this Ligand-Target Pair
Target4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6(Homo sapiens (Human))
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataKi: 376nMAssay Description:Compound was tested for binding affinity against Fucosyltransferase 6More data for this Ligand-Target Pair
Target4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6(Homo sapiens (Human))
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataKi: 437nMAssay Description:Compound was tested for binding affinity against Fucosyltransferase 6More data for this Ligand-Target Pair
Target4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6(Homo sapiens (Human))
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataKi: 511nMAssay Description:Compound was tested for binding affinity against Fucosyltransferase 6More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica
Academia Sinica
Affinity DataKi: 520nM ΔG°: -35.9kJ/mole IC50: 1.00E+3nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair