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Found 167 with Last Name = 'twigg' and Initial = 'dg'
TargetCoagulation factor X(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50598056(CHEMBL403671)
Affinity DataKi: <0.300nMAssay Description:Binding affinity to Coagulation factor Xa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50598057(CHEMBL254337)
Affinity DataKi: <0.300nMAssay Description:Binding affinity to Coagulation factor Xa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50228954((E)-2-(6-(3-(2-(5-chlorothiophen-2-yl)vinylsulfona...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to Coagulation factor Xa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50228935((E)-2-(5-chloro-thiophen-2-yl)-ethenesulfonic acid...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to Coagulation factor Xa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50228946((E)-2-(5-chlorothiophen-2-yl)-N-(2-oxo-1-(5-(2-(tr...)
Affinity DataKi:  6nMAssay Description:Binding affinity to Coagulation factor Xa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50228933((E)-2-(5-chlorothiophen-2-yl)-N-(1-(5-(2-(N-methyl...)
Affinity DataKi:  9.10nMAssay Description:Binding affinity to Coagulation factor Xa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50228939((E)-2-(6-(3-(2-(5-chlorothiophen-2-yl)vinylsulfona...)
Affinity DataKi:  12nMAssay Description:Binding affinity to Coagulation factor Xa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50228937((E)-2-(5-chloro-thiophen-2-yl)-ethenesulfonic acid...)
Affinity DataKi:  14nMAssay Description:Binding affinity to Coagulation factor Xa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50228929((E)-2-(5-chlorothiophen-2-yl)-N-(1-(5-(2-isopropox...)
Affinity DataKi:  180nMAssay Description:Binding affinity to Coagulation factor Xa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50228942((E)-N-(1-(5-(2-tert-butylphenyl)pyridin-2-yl)-2-ox...)
Affinity DataKi:  2.33E+3nMAssay Description:Binding affinity to Coagulation factor Xa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin S(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM240596(US9409882, 1)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of Cathepsin S (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCathepsin S(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM130413(US8822505, 13)
Affinity DataIC50:  1nMAssay Description:Inhibition of Cathepsin S (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin S(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM130402(US8822505, 2)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of Cathepsin S (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM50546218(CHEMBL4741490 | US11466016, Example 114)
Affinity DataIC50:  3nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575964((1R,2S,3S,5S)-8-[3-(5- chloro-3-methoxy- quinoxali...)
Affinity DataIC50:  3nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575962((1R,2S,3S,5S)-8-[3-(3,4- Dichloro-2-methyl-2H- ind...)
Affinity DataIC50:  3.60nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575913(US11466016, Example 41 | exo-8-[7-(3,4- dichloro-2...)
Affinity DataIC50:  3.60nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575966(US11466016, Example 98 | {6-[(1R,2S,3S,5S)- 3-amin...)
Affinity DataIC50:  4nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM155979(US9018214, 30)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of XIAP BIR3 domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575896(US11466016, Example 24 | endo-8-[7-(3,4- dichloro-...)
Affinity DataIC50:  4.30nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575937(5-{3-[endo-3-amino-8- azabicyclo[3.2.1]octan- 8-yl...)
Affinity DataIC50:  4.40nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575965(7-{6-[(1R,2S,3S,5S)- 3-amino-2-fluoro-8- azabicycl...)
Affinity DataIC50:  4.70nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProcathepsin L(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM130413(US8822505, 13)
Affinity DataIC50:  5nMAssay Description:Inhibition of human Cathepsin LMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575995(5-{6- [(1R,2S,3S,5S)-3- amino-2-fluoro-8- azabi...)
Affinity DataIC50:  5nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575951(US11466016, Example 80 | {6-[(1R,2S,3S,5S)-3- amin...)
Affinity DataIC50:  5.20nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575895(6-{3-[endo-3- amino-8- azabicyclo[3.2.1] octan-8-y...)
Affinity DataIC50:  5.20nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575988(US11466016, Example 122 | {3- [(1R,2S,3S,5S)-3- am...)
Affinity DataIC50:  5.20nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575983(US11466016, Example 118 | {6-[(1R,2S,3S,5S)- 3-ami...)
Affinity DataIC50:  5.30nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575915(US11466016, Example 43 | endo-8-{7-[7- chloro-2- (...)
Affinity DataIC50:  5.80nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM155971(US9018214, 22)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of XIAP BIR3 domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575886(US11466016, Example 15 | endo-8-[7-(7- chloro-2- m...)
Affinity DataIC50:  5.90nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575999(US11466016, Example 133 | {6-[endo-3-amino-8- aza...)
Affinity DataIC50:  6nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575908(2-(5-{3-[endo- 3-amino-8- azabicyclo[3.2.1] octan-...)
Affinity DataIC50:  6nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM576010(US11466016, Example 143 | {6-[(1R,2S,3S,5S)- 3-am...)
Affinity DataIC50:  6.10nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575884(US11466016, Example 13 | endo-8-[7-(7- chloro-1,3-...)
Affinity DataIC50:  6.20nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575975(US11466016, Example 108 | {6-[(1R,2S,3S,5S)- 3-ami...)
Affinity DataIC50:  6.60nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575941(US11466016, Example 69 | endo-8-(7-{4-chloro-2- [(...)
Affinity DataIC50:  6.80nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575916((6-{3-[endo-3- amino-8- azabicyclo [3.2.1]octan- 8...)
Affinity DataIC50:  6.80nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575911(US11466016, Example 39 | endo-8-{7-[7- chloro-2- (...)
Affinity DataIC50:  6.90nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575977(US11466016, Example 110 | [6-(4-amino-4- methylpip...)
Affinity DataIC50:  7nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575934(5-{3-[endo-3-amino-8- azabicyclo[3.2.1]octan- 8-yl...)
Affinity DataIC50:  7.10nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575991(6-[3,9- diazabicyclo[3.3.1] nonan-9-yl]-3-(3,4- ...)
Affinity DataIC50:  7.10nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575959(US11466016, Example 88 | {6-[endo-3-amino-8- azabi...)
Affinity DataIC50:  7.10nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575957(US11466016, Example 86 | {6-[3,8- diazabicyclo[3.2...)
Affinity DataIC50:  7.20nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575994(US11466016, Example 128 | {6-[endo-3- amino-8- az...)
Affinity DataIC50:  7.30nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575955(US11466016, Example 84 | {6-[(1R,2S,3S,5S)-3- amin...)
Affinity DataIC50:  7.40nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575979(US11466016, Example 113 | {6-[endo-3-amino- 8-aza-...)
Affinity DataIC50:  7.40nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM576015((1S,2S,3S,5R)-8-[3- (7-chloro-2-methyl- 1,3-benz...)
Affinity DataIC50:  7.40nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575981(US11466016, Example 116 | {6-[endo-3-amino- 3-meth...)
Affinity DataIC50:  7.5nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575956(US11466016, Example 85 | {6-[(1S,2S,3S,5R)-3- amin...)
Affinity DataIC50:  7.5nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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