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Found 275 with Last Name = 'yang' and Initial = 'hy'
TargetTranslocator protein(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50159089(CHEMBL180523 | N,N-Dibutyl-2-[6,8-dichloro-2-(4-ch...)
Affinity DataKi:  2.70nMAssay Description:Inhibition of TSPO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50045877(2-(2-(4-fluorophenyl)-1H-indol-3-yl)-N,N-dihexylac...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of TSPO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM22032(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Affinity DataKi:  8.90nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat cerebral cortex membranes after 60 mins by microbeta liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50210940(CHEMBL3948914)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat cerebral cortex membranes after 60 mins by microbeta liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325294(5-((6-(4-hydroxy-3-methoxyphenyl)-2-oxoindolin-3-y...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325307(CHEMBL1223408 | N-(2-(diethylamino)ethyl)-5-((6-(4...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325308(5-((6-(4-hydroxyphenyl)-2-oxoindolin-3-ylidene)met...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325292(CHEMBL1223182 | N-(2-(dimethylamino)ethyl)-5-((6-(...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325296(CHEMBL1223263 | N-(3-(1H-imidazol-1-yl)propyl)-5-(...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325310(CHEMBL1223478 | N-(3-(1H-imidazol-1-yl)propyl)-5-(...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325306(CHEMBL1223407 | N-(2-(dimethylamino)ethyl)-5-((6-(...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325293(CHEMBL1223183 | N-(2-(diethylamino)ethyl)-5-((6-(4...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325309(5-((6-(4-hydroxyphenyl)-2-oxoindolin-3-ylidene)met...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50185957(CHEMBL205767 | N-(2-isopropoxybenzyl)-N-(4-chloro-...)
Affinity DataIC50:  0.920nMAssay Description:Inhibition of TSPO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325295(5-((6-(4-hydroxy-3-methoxyphenyl)-2-oxoindolin-3-y...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant RET expressed in sf21 cells using Poly(Glu:Tyr) as substrate in presence of [gamma32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM22032(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of TSPO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM22032(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat cerebral cortex membranes after 60 mins by microbeta liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetTranslocator protein(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50210943(CHEMBL3970955)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of TSPO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50465100(CHEMBL4282154)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate incubated for 20 mins followed by substrate addition measured after 2 mins by El...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325287(CHEMBL1223044 | N-(2-(dimethylamino)ethyl)-5-((6-(...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50465096(CHEMBL4293418)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate incubated for 20 mins followed by substrate addition measured after 2 mins by El...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325291(CHEMBL1223118 | N-(3-(1H-imidazol-1-yl)propyl)-5-(...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325304(5-((6-(4-hydroxyphenyl)-2-oxoindolin-3-ylidene)met...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325289(5-((6-(4-hydroxy-3-methoxyphenyl)-2-oxoindolin-3-y...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325302(CHEMBL1223338 | N-(2-(diethylamino)ethyl)-5-((6-(4...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325303(5-((6-(4-hydroxyphenyl)-2-oxoindolin-3-ylidene)met...)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50465093(CHEMBL4286601)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate incubated for 20 mins followed by substrate addition measured after 2 mins by El...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50465101(CHEMBL4278686)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate incubated for 20 mins followed by substrate addition measured after 2 mins by El...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM14649((3Z)-6-(4-hydroxy-3-methoxyphenyl)-3-(1H-pyrrol-2-...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170222(CHEMBL3805771)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant RET expressed in sf21 cells using Poly(Glu:Tyr) as substrate in presence of [gamma32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325301(CHEMBL1223337 | N-(2-(dimethylamino)ethyl)-5-((6-(...)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325305(CHEMBL1223406 | N-(3-(1H-imidazol-1-yl)propyl)-5-(...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170218(CHEMBL3804952)
Affinity DataIC50:  8nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 kinase domain (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using JH3 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170223(CHEMBL3805330)
Affinity DataIC50:  8nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 kinase domain (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using JH3 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325290(5-((6-(4-hydroxy-3-methoxyphenyl)-2-oxoindolin-3-y...)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170217(CHEMBL3805114)
Affinity DataIC50:  10nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 kinase domain (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using JH3 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325288(CHEMBL1223115 | N-(2-(diethylamino)ethyl)-5-((6-(4...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50:  10nMAssay Description:Inhibition of BCR fused full length human recombinant N-terminal His-tagged ABL (2 to 1130 residues) expressed in baculovirus expression system using...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50:  10nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 kinase domain (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using JH3 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170215(CHEMBL3806261)
Affinity DataIC50:  11nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 kinase domain (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using JH3 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325286((Z)-5-((6-(4-hydroxy-3-methoxyphenyl)-2-oxoindolin...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170171(CHEMBL3805029)
Affinity DataIC50:  12nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 kinase domain (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using JH3 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325284((Z)-6-(4-hydroxy-3-methoxyphenyl)-3-((5-methylsele...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325297((Z)-6-(4-hydroxyphenyl)-3-(selenophen-2-ylmethylen...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170216(CHEMBL3805956)
Affinity DataIC50:  14nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 kinase domain (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using JH3 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325300((Z)-5-((6-(4-hydroxyphenyl)-2-oxoindolin-3-ylidene...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170222(CHEMBL3805771)
Affinity DataIC50:  16nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 kinase domain (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using JH3 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50465097(CHEMBL4290039)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged GSK-3beta expressed in Sf9 insect cells using prephosphorylated polypeptide as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325298((Z)-6-(4-hydroxyphenyl)-3-((5-methylselenophen-2-y...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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