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Found 6489 with Last Name = 'wu' and Initial = 'k'
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pharm-Eco Laboratories

Curated by ChEMBL
LigandPNGBDBM50095611(CHEMBL356750 | [3-(3,4-Dichloro-phenyl)-indan-1-yl...)
Affinity DataKi:  0.0600nMAssay Description:Binding affinity against cloned serotonin human transporter using 40-80 PM [125I]RTIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pharm-Eco Laboratories

Curated by ChEMBL
LigandPNGBDBM50095611(CHEMBL356750 | [3-(3,4-Dichloro-phenyl)-indan-1-yl...)
Affinity DataKi:  0.0600nMAssay Description:Binding affinity against cloned serotonin human transporter using 40-80 PM [125I]RTIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pharm-Eco Laboratories

Curated by ChEMBL
LigandPNGBDBM50369770(CHEMBL1788140)
Affinity DataKi:  0.330nMAssay Description:Binding affinity against cloned serotonin human transporter using 40-80 PM [125I]RTIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50591761(CHEMBL5189562)
Affinity DataKi:  0.800nMAssay Description:Inhibition of coagulation factor Xa (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50038046(2-((S)-9-Bromo-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-...)
Affinity DataKi:  0.960nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50591723(CHEMBL5185347)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313984(2-(2,2,3,3-tetrafluoro-3-(3-(5-hydroxypyridin-2-yl...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pharm-Eco Laboratories

Curated by ChEMBL
LigandPNGBDBM50095629(CHEMBL147983 | [3-(3,4-Dichloro-phenyl)-indan-1-yl...)
Affinity DataKi:  2nMAssay Description:Binding affinity against cloned serotonin human transporter using 40-80 PM [125I]RTIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Kuang Tien General Hospital

Curated by ChEMBL
LigandPNGBDBM50272772(10-(4-Amino-butyl)-19-(2-amino-3-phenyl-propionyla...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity to human SSTR2AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50038055(((S)-9-Bromo-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-py...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pharm-Eco Laboratories

Curated by ChEMBL
LigandPNGBDBM50095619(CHEMBL147950 | [3-(3,4-Dichloro-phenyl)-indan-1-yl...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity against cloned serotonin human transporter using 40-80 PM [125I]RTIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50038047(2-(9-Bromo-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-pyri...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313977(2-(3-(3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50591722(CHEMBL5208012)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50091831((R)-8,9-Dichloro-2,3,4,4a-tetrahydro-1H,6H-pyrazin...)
Affinity DataKi:  3nMAssay Description:Agonist activity at 5-HT2C receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50284815(2-((S)-9-Chloro-6-methyl-2,3-dioxo-2,3,6,7-tetrahy...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50591721(CHEMBL5208606)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)
Affinity DataKi:  3.80nMAssay Description:Inhibition of human cloned CA12 catalytic domain by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM23533(2-{3-[3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pharm-Eco Laboratories

Curated by ChEMBL
LigandPNGBDBM50095631(CHEMBL146332 | [3-(3,4-Dichloro-phenyl)-indan-1-yl...)
Affinity DataKi:  4nMAssay Description:Inhibition of reuptake of [3H]5-HT (20 nM) by serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313976(2-({3-[3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50284813(((S)-9-Chloro-6-methyl-2,3-dioxo-2,3,6,7-tetrahydr...)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Medical University of South Carolina

Curated by PDSP Ki Database
LigandPNGBDBM50008781(7-(3-(2-ethyl-N-phenylhydrazinecarboxamide)-7-oxa-...)
Affinity DataKi:  4.70nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pharm-Eco Laboratories

Curated by ChEMBL
LigandPNGBDBM50095630(CHEMBL356552 | [3-(3,4-Dichloro-phenyl)-indan-1-yl...)
Affinity DataKi:  4.70nMAssay Description:Binding affinity against cloned serotonin human transporter using 40-80 PM [125I]RTIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pharm-Eco Laboratories

Curated by ChEMBL
LigandPNGBDBM50095618(CHEMBL341898 | Indatraline | [3-(3,4-Dichloro-phen...)
Affinity DataKi:  4.80nMAssay Description:Inhibition of reuptake of [3H]5-HT (20 nM) by serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50297829(7-(pyrrolidin-1-ylmethyl)pyrrolo[1,2-a]quinoxalin-...)
Affinity DataKi:  5nMAssay Description:Inhibition of PARP-1 (unknown origin)More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pharm-Eco Laboratories

Curated by ChEMBL
LigandPNGBDBM50095618(CHEMBL341898 | Indatraline | [3-(3,4-Dichloro-phen...)
Affinity DataKi:  5nMAssay Description:Binding affinity against cloned serotonin human transporter using 40-80 PM [125I]RTIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM10888(1,2-benzoxazol-3-ylmethanesulfonamide | CHEMBL750 ...)
Affinity DataKi:  5nMAssay Description:Inhibition of human cloned CA9 catalytic domain by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCarbonic anhydrase 2(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)
Affinity DataKi:  5nMAssay Description:Inhibition of human cloned CA2 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50284817((9-Chloro-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-pyrid...)
Affinity DataKi:  5.10nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pharm-Eco Laboratories

Curated by ChEMBL
LigandPNGBDBM50095619(CHEMBL147950 | [3-(3,4-Dichloro-phenyl)-indan-1-yl...)
Affinity DataKi:  5.5nMAssay Description:Inhibition of reuptake of [3H]5-HT (20 nM) by serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataKi:  5.70nMAssay Description:Inhibition of human cloned CA12 catalytic domain by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50148831(CHEMBL3770342)
Affinity DataKi:  6.20nMAssay Description:Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pharm-Eco Laboratories

Curated by ChEMBL
LigandPNGBDBM50095611(CHEMBL356750 | [3-(3,4-Dichloro-phenyl)-indan-1-yl...)
Affinity DataKi:  6.30nMAssay Description:Inhibition of reuptake of [3H]5-HT (20 nM) by serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pharm-Eco Laboratories

Curated by ChEMBL
LigandPNGBDBM50095611(CHEMBL356750 | [3-(3,4-Dichloro-phenyl)-indan-1-yl...)
Affinity DataKi:  6.30nMAssay Description:Inhibition of reuptake of [3H]5-HT (20 nM) by serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50284818(2-(9-Chloro-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-pyr...)
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50148833(CHEMBL3770106)
Affinity DataKi:  7.20nMAssay Description:Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313978(2-(3-(3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313978(2-(3-(3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pharm-Eco Laboratories

Curated by ChEMBL
LigandPNGBDBM50095629(CHEMBL147983 | [3-(3,4-Dichloro-phenyl)-indan-1-yl...)
Affinity DataKi:  8.10nMAssay Description:Binding affinity against cloned human dopamine transporter using 40-80 pM [125I]RTI.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pharm-Eco Laboratories

Curated by ChEMBL
LigandPNGBDBM50095611(CHEMBL356750 | [3-(3,4-Dichloro-phenyl)-indan-1-yl...)
Affinity DataKi:  8.70nMAssay Description:Binding affinity against cloned human dopamine transporter using 40-80 pM [125I]RTI.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pharm-Eco Laboratories

Curated by ChEMBL
LigandPNGBDBM50095611(CHEMBL356750 | [3-(3,4-Dichloro-phenyl)-indan-1-yl...)
Affinity DataKi:  8.70nMAssay Description:Binding affinity against cloned human dopamine transporter using 40-80 pM [125I]RTI.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50297828(7-(piperidin-1-ylmethyl)pyrrolo[1,2-a]quinoxalin-4...)
Affinity DataKi:  9nMAssay Description:Inhibition of PARP-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50591724(CHEMBL129149)
Affinity DataKi:  9.60nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50038043((9-Bromo-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-pyrido...)
Affinity DataKi:  9.90nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBcl-2-related protein A1(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50558851(CHEMBL4782684)
Affinity DataKi:  10nMAssay Description:Covalent binding affinity to human Bcl2A1 by FBid based FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(1B) dopamine receptor(Homo sapiens (Human))
State Key Laboratory Of Drug Research

Curated by ChEMBL
LigandPNGBDBM50088341(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Affinity DataKi: <10nMAssay Description:Antagonist activity at dopamine D5 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
State Key Laboratory Of Drug Research

Curated by ChEMBL
LigandPNGBDBM50088341(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Affinity DataKi: <10nMAssay Description:Antagonist activity at dopamine D1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313979(2-(1-((3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataKi:  12nMAssay Description:Inhibition of human cloned CA2 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
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