Affinity DataIC50: 2.20nMAssay Description:Binding affinity to GST-tagged MDM2 (unknown origin) assessed as inhibition of interaction with His-tagged p53 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Binding affinity to GST-tagged MDM2 (unknown origin) assessed as inhibition of interaction with His-tagged p53 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.60nMAssay Description:Binding affinity to GST-tagged MDM2 (unknown origin) assessed as inhibition of interaction with His-tagged p53 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.5nMAssay Description:Binding affinity to GST-tagged MDM2 (unknown origin) assessed as inhibition of interaction with His-tagged p53 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Binding affinity to GST-tagged MDM2 (unknown origin) assessed as inhibition of interaction with His-tagged p53 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Binding affinity to GST-tagged MDM2 (unknown origin) assessed as inhibition of interaction with His-tagged p53 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Binding affinity to GST-tagged MDM2 (unknown origin) assessed as inhibition of interaction with His-tagged p53 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Binding affinity to GST-tagged MDM2 (unknown origin) assessed as inhibition of interaction with His-tagged p53 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 61.9nMAssay Description:Inhibition of CDK4/Cyclin D1 expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 70.4nMAssay Description:Inhibition of CDK4/Cyclin D1 expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 70.7nMAssay Description:Inhibition of CDK4/Cyclin D1 expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of MDM2 binding to p53More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 93nMAssay Description:Inhibition of CDK4/Cyclin D1 expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 103nMAssay Description:Inhibition of CDK4/Cyclin D1 expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 107nMAssay Description:Inhibition of CDK4/Cyclin D1 expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of MDM2 binding to p53More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of human His-tagged p53 (1 to 132 amino acid residues)/GST-tagged MDM2 L33E mutant (25 to 108 amino acid residues) interaction by HTRF ass...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of GST-tagged MDM2 binding to p53 by ELISAMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 151nMAssay Description:Inhibition of CDK4/Cyclin D1 expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of GST-tagged MDM2 binding to p53 by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of GST-tagged MDM2 binding to p53 by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of GST-tagged MDM2 binding to p53 by ELISAMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 203nMAssay Description:Inhibition of CDK4/Cyclin D1 expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 209nMAssay Description:Inhibition of CDK4/Cyclin D1 expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 236nMAssay Description:Inhibition of CDK4/Cyclin D1 expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of GST-tagged MDM2 binding to p53 by ELISAMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 262nMAssay Description:Inhibition of CDK4/Cyclin D1 expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 340nMAssay Description:Inhibition of GST-tagged MDM2 binding to p53 by ELISAMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 492nMAssay Description:Inhibition of CDK2/Cyclin E expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 729nMAssay Description:Inhibition of CDK2/Cyclin E expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 763nMAssay Description:Inhibition of CDK2/Cyclin E expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 840nMAssay Description:Inhibition of GST-tagged MDM2 binding to p53 by ELISAMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of CDK2/Cyclin E expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of GST-tagged MDM2 binding to p53 by ELISAMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of CDK4/Cyclin D1 expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of GST-tagged MDM2 binding to p53 by ELISAMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 1.47E+3nMAssay Description:Inhibition of CDK2/Cyclin E expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 1.63E+3nMAssay Description:Inhibition of CDK2/Cyclin E expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 1.75E+3nMAssay Description:Inhibition of CDK2/Cyclin E expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of GST-tagged MDM2 binding to p53 by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of GST-tagged MDM2 binding to p53 by ELISAMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 1.92E+3nMAssay Description:Inhibition of CDK2/Cyclin E expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 1.96E+3nMAssay Description:Inhibition of CDK4/Cyclin D1 expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of GST-tagged MDM2 binding to p53 by ELISAMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 2.73E+3nMAssay Description:Inhibition of CDK2/Cyclin E expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 2.76E+3nMAssay Description:Inhibition of CDK4/Cyclin D1 expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 2.87E+3nMAssay Description:Inhibition of CDK2/Cyclin E expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 2.99E+3nMAssay Description:Inhibition of CDK2/Cyclin E expressed in Sf9 cells assessed as inhibition of Rb phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of GST-tagged MDM2 binding to p53 by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of GST-tagged MDM2 binding to p53 by ELISAMore data for this Ligand-Target Pair