Compile Data Set for Download or QSAR
maximum 50k data
Found 497 with Last Name = 'bishop' and Initial = 'wr'
LigandPNGBDBM50289150(Acetic acid (7E,11E)-(1S,2R,4R,14S,15R)-4,8,12-tri...)
Affinity DataKi:  170nMAssay Description:Kinetic parameter for inihibiton of farnesyl protein transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079090(CHEMBL90435 | [(4-{2-[4-((R)-3,10-Dibromo-8-chloro...)
Affinity DataIC50:  0.800nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079085(5-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  0.800nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079075(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of [3H]-FPP incorporation into His6-H-Ras-CVLS by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14457((+)-4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo...)
Affinity DataIC50:  1.30nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50109870(4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo...)
Affinity DataIC50:  1.70nMAssay Description:FPT inhibitory activity was determined by the ability of the compound to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-ras-C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14461((+)-4-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo...)
Affinity DataIC50:  1.80nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079079(1-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM14459((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079074(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14459((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...)
Affinity DataIC50:  1.90nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079089(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079084(CHEMBL432573 | [(4-{2-[4-((R)-3,10-Dibromo-8-chlor...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079083(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of Hras Farnesyl protein transferase(FPT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079073(2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  2.10nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079091(2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of [3H]-FPP incorporation into His6-H-Ras-CVLS by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079076(5-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  2.20nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14473((-)-1-(8-Chloro-3,7-dibromo-6,11-dihydro-5H-benzo-...)
Affinity DataIC50:  2.30nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14467((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...)
Affinity DataIC50:  2.5nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079070(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of Hras Farnesyl protein transferase(FPT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14469((-)-4-(8-Chloro-3,7-dibromo-6,11-dihydro-5H-benzo-...)
Affinity DataIC50:  2.60nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079086(3-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of Hras Farnesyl protein transferase(FPT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079077(2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  2.70nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079072(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)
Affinity DataIC50:  3.10nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14477((-)-4-[2-[4-(3,7-Dibromo-8-chloro-6,11-dihydro-5Hb...)
Affinity DataIC50:  3.10nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50078819(1-[4-((R)-3-Bromo-10-methoxy-8-methyl-6,11-dihydro...)
Affinity DataIC50:  3.60nMAssay Description:In vitro inhibition of human FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14463((+)-4-(3-Bromo-8,10-dichloro-6,11-dihydro-5H-benzo...)
Affinity DataIC50: <3.80nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079088(1-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  4.30nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079081(2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of [3H]-FPP incorporation into His6-H-Ras-CVLS by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14471((-)-4-[2-[4-(3,7-Dibromo-8-chloro-6,11-dihydro-5H-...)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079092((S)-2-Amino-1-(4-{2-[4-((R)-3,10-dibromo-8-chloro-...)
Affinity DataIC50:  5.20nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079087(2-[1-(2-Amino-acetyl)-piperidin-4-yl]-1-[4-((R)-3,...)
Affinity DataIC50:  5.30nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079080(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of [3H]-FPP incorporation into His6-H-Ras-CVLS by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50109872(4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohep...)
Affinity DataIC50:  6nMAssay Description:FPT inhibitory activity was determined by the ability of the compound to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-ras-C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14475((-)-1-(3-Bromo-7,8-dichloro-6,11-dihydro-5H-benzo-...)
Affinity DataIC50:  6nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50109858(4-({[4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyc...)
Affinity DataIC50:  6nMAssay Description:FPT inhibitory activity was determined by the ability of the compound to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-ras-C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079091(2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  6nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177643((R)-[8-chloro-6-(1-piperazinyl)-1H-benzo[5,6]]cycl...)
Affinity DataIC50:  7nMAssay Description:Inhibition of farnesyltransferase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079083(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Affinity DataIC50:  7nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079071(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of [3H]-FPP incorporation into His6-H-Ras-CVLS by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079078((R)-2-Amino-1-(4-{2-[4-((R)-3,10-dibromo-8-chloro-...)
Affinity DataIC50:  7.90nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50109878(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Affinity DataIC50:  8.20nMAssay Description:FPT inhibitory activity was determined by the ability of the compound to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-ras-C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079074(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)
Affinity DataIC50:  8.5nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079071(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)
Affinity DataIC50:  9nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079088(1-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  9nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM14459((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...)
Affinity DataIC50:  10nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079070(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Affinity DataIC50:  10nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079073(2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  10nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50063416(1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]c...)
Affinity DataIC50:  12nMAssay Description:In vitro inhibition of farnesyltransferase farnesylation of the H-ras oncogeneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50109871(4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohep...)
Affinity DataIC50:  12nMAssay Description:FPT inhibitory activity was determined by the ability of the compound to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-ras-C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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