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Found 113 with Last Name = 'bailly' and Initial = 'c'
TargetProtein phosphatase 1B(Homo sapiens (Human))
Oncowitan

Curated by ChEMBL
LigandPNGBDBM50589477(CHEMBL5188453)
Affinity DataKi:  520nMAssay Description:Binding affinity to PPM1B (unknown origin) expressed in Escherichia coli BL21 assessed as inhibition constant using pNPP as substrate by absorbance b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Oncowitan

Curated by ChEMBL
LigandPNGBDBM50606525(CHEMBL5218452)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of AXL (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50605273(CHEMBL5194902)
Affinity DataIC50:  4nMAssay Description:Inhibition of human PD-1/PD-L1 interaction in CHO-K1 cells transfected with PD-1-YFP/SHP-2-CFP and measured by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50605259(CHEMBL5176505)
Affinity DataIC50:  7nMAssay Description:Inhibition of human PD-1/PD-L1 interaction in CHO-K1 cells transfected with PD-1-YFP/SHP-2-CFP and measured by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50605270(CHEMBL5207924)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of human PD-1/PD-L1 interaction in CHO-K1 cells transfected with PD-1-YFP/SHP-2-CFP and measured by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50605281(CHEMBL5194957)
Affinity DataIC50:  9nMAssay Description:Inhibition of human PD-1/PD-L1 interaction in CHO-K1 cells transfected with PD-1-YFP/SHP-2-CFP and measured by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50216159(5-hydroxy-pyrrolo[3',4':5,6]indolizino[8,7-b]indol...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50605266(CHEMBL5171729)
Affinity DataIC50:  17nMAssay Description:Inhibition of human PD-1/PD-L1 interaction in CHO-K1 cells transfected with PD-1-YFP/SHP-2-CFP and measured by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50216171(CHEMBL393545 | pyrrolo[3',4':5,6]indolizino[8,7-b]...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50216161(5-bromo-pyrrolo[3',4':51,3-(2H,8H)-dione,6]indoliz...)
Affinity DataIC50:  66nMAssay Description:Inhibition of human Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50216165(1,11-dihydro-1,3,5,11-tetraaza-benzo[a]trindene-4,...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50216163(5-chloro-pyrrolo[3',4':5,6]indolizino[8,7-b]indole...)
Affinity DataIC50:  89nMAssay Description:Inhibition of human Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50605275(CHEMBL374252)
Affinity DataIC50:  92nMAssay Description:Inhibition of human PD-1/PD-L1 interaction in CHO-K1 cells transfected with PD-1-YFP/SHP-2-CFP and measured by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50605271(CHEMBL5203947)
Affinity DataIC50:  98nMAssay Description:Inhibition of human PD-1/PD-L1 interaction in CHO-K1 cells transfected with PD-1-YFP/SHP-2-CFP and measured by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)
Affinity DataIC50:  124nMAssay Description:Inhibition of human PD-1/PD-L1 interaction in CHO-K1 cells transfected with PD-1-YFP/SHP-2-CFP and measured by FRET assayMore data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50605267(CHEMBL5177267)
Affinity DataIC50:  143nMAssay Description:Inhibition of human PD-1/PD-L1 interaction in CHO-K1 cells transfected with PD-1-YFP/SHP-2-CFP and measured by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50180964(5-hydroxybenzo(a)pyrrolo(3,4-c)carbazole-1,3(2H,8H...)
Affinity DataIC50:  250nMAssay Description:Inhibitory activity against CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
Oncowitan

Curated by ChEMBL
LigandPNGBDBM50051340(2'-Hydroxyflavanone | 2'-hydroxy-flavanone | 2-(2-...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human recombinant His-tagged AKR1C3 expressed in Escherichia coli BL21(DE3) incubated for 30 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50605258(CHEMBL5186432)
Affinity DataIC50:  359nMAssay Description:Inhibition of human PD-1/PD-L1 interaction in CHO-K1 cells transfected with PD-1-YFP/SHP-2-CFP and measured by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50216157(11H-2,5,11,11b-Tetraaza-benzo[a]trindene-4,6-dione...)
Affinity DataIC50:  440nMAssay Description:Inhibition of human Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50216158(5-benzyloxy-pyrrolo[3',4':5,6]indolizino[8,7-b]ind...)
Affinity DataIC50:  640nMAssay Description:Inhibition of human Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50605265(CHEMBL5207258)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human PD-1/PD-L1 interaction in CHO-K1 cells transfected with PD-1-YFP/SHP-2-CFP and measured by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM7440(2,4,6-Trimethyl-N-(3-oxo-1,2,3,6-tetrahydro-2,4,6-...)
Affinity DataIC50:  1.50E+3nMpH: 7.5 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50216162(11H-3a,5,10,11-tetraaza-benzo[a]trindene-4,6-dione...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7435(5-Aminomethyl-1,2-dihydro-6H-2,4,6-triazacyclopent...)
Affinity DataIC50:  5.50E+3nMpH: 7.5 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7438(10-[2-(dimethylamino)ethyl]-8-methyl-4,7,10-triaza...)
Affinity DataIC50:  7.00E+3nMpH: 7.5 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50372625(CHEMBL406538)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of topoisomerase 1-mediated DNA relaxationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7439(2-(dimethylamino)-N-({5-oxo-4,7,10-triazatetracycl...)
Affinity DataIC50:  8.00E+3nMpH: 7.5 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50134580(1,2,3,8-tetrahydro-benzo[a]pyrrolo[3,4-c]carbazole...)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibitory activity against CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50372627(CHEMBL406537)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of topoisomerase 1-mediated DNA relaxationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Oncowitan

Curated by ChEMBL
LigandPNGBDBM50051340(2'-Hydroxyflavanone | 2'-hydroxy-flavanone | 2-(2-...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK-293 cells incubated for 10 minsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50180960(5-hydroxy-5H-Furo(3,4-c)benzo(a)pyrrolo(3,4-c)carb...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50180959(2-(2-dimethylaminoethyl)-5-hydroxybenzo(a)pyrrolo(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50180963(2-(2-(1H-imidazol-4-yl)ethyl)benzo(a)pyrrolo(3,4-c...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50180958(2-(2-dimethylaminoethyl)benzo(a)pyrrolo(3,4-c)carb...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50180966(2-methyl-5-hydroxybenzo(a)pyrrolo(3,4-c)carbazole-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50180965(2-(2-hydroxy-1-(hydroxymethyl)ethyl)-5-hydroxybenz...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50180962(2-(2-(1H-imidazol-4-yl)ethyl)-5-hydroxybenzo(a)pyr...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50180961(5H-Furo(3,4-c)benzo(a)pyrrolo(3,4-c)carbazole-1,3(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50180957(2-(2-hydroxy-1-(hydroxymethyl)ethyl)benzo(a)pyrrol...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50180956(2-methylbenzo(a)pyrrolo(3,4-c)carbazole-1,3(2H,8H)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7430(5-Methyl-6-(2-trimethylsilanyl-ethoxymethyl)-1,2-d...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7450(pyrrolocarbazole deriv. 27b | {[({2-benzyl-4-methy...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7449(pyrrolocarbazole deriv. 27a | {[({2,4-dimethyl-1,3...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7448(N-[(2-benzyl-4-methyl-1,3-dioxo-5-{[2-(trimethylsi...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7447(N-[(2,4-dimethyl-1,3-dioxo-5-{[2-(trimethylsilyl)e...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7446(N-[(2-benzyl-4-methyl-1,3-dioxo-5-{[2-(trimethylsi...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7445(N-[(2,4-dimethyl-1,3-dioxo-5-{[2-(trimethylsilyl)e...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7444(10-(aminomethyl)-2-benzyl-4-methyl-5-{[2-(trimethy...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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