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Found 763 with Last Name = 'becker' and Initial = 'm'
TargetCoagulation factor X(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50080514(3-[(R)-3-(7-Methoxy-naphthalene-2-sulfonylamino)-2...)
Affinity DataKi:  0.0470nMAssay Description:Compound was evaluated for the inhibition of human Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM14059(4-hydroxy-3-[[(3S)-2-oxo-3-(9-thia-5-azabicyclo[4....)
Affinity DataKi:  0.700nM ΔG°:  -51.7kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM14059(4-hydroxy-3-[[(3S)-2-oxo-3-(9-thia-5-azabicyclo[4....)
Affinity DataKi:  0.700nMAssay Description:Binding affinity against serine protease factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50123781(4-(4-Amino-quinazolin-7-ylmethyl)-1-(6-chloro-benz...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity (in vitro) of the compound towards human Coagulation factor X was determined at 10 mg/kg peroral doseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM12597(CHEMBL48046 | RPR128515 | methyl (2R,3R)-2-{3-[ami...)
Affinity DataKi:  0.900nM ΔG°:  -51.1kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM12597(CHEMBL48046 | RPR128515 | methyl (2R,3R)-2-{3-[ami...)
Affinity DataKi:  0.900nM ΔG°:  -51.1kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50111966(1-(4-Amino-quinazolin-7-ylmethyl)-4-(6-chloro-benz...)
Affinity DataKi:  1nMAssay Description:Inhibition of Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM12594(4-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXO...)
Affinity DataKi:  1nMAssay Description:Inhibition of Coagulation factor XaMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50187381(CHEMBL209324 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM12596(4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity (in vitro) of the compound towards human Coagulation factor X was determined at 5 mg/kg peroral doseMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM12596(4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1...)
Affinity DataKi:  1.10nM ΔG°:  -50.6kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50187394(CHEMBL207220 | N-(3-{4-[4-(cyclohexylmethanesulfon...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM12594(4-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXO...)
Affinity DataKi:  1.30nM ΔG°:  -50.2kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50081505(3-[(S)-3-(5-Chloro-thieno[3,2-b]pyridine-2-sulfony...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity against serine protease factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50081499(4-Hydroxy-3-[(S)-2-oxo-3-(thieno[2,3-c]pyridine-2-...)
Affinity DataKi:  2nMAssay Description:Binding affinity against serine protease Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50081512(3-[(S)-3-(4-Chloro-thieno[3,2-c]pyridine-2-sulfony...)
Affinity DataKi:  2nMAssay Description:Binding affinity against serine protease factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM13304(4-hydroxy-3-[((3S)-2-oxo-3-{[(5-pyridin-3-ylthien-...)
Affinity DataKi:  2nMAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM12595(4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-1-{[1-(2-...)
Affinity DataKi:  3nMAssay Description:Binding affinity (in vitro) of the compound towards human Coagulation factor X was determined at 10 mg/kg peroral doseMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50081510(4-Amino-3-[(S)-3-(5-chloro-thieno[3,2-b]pyridine-2...)
Affinity DataKi:  3nMAssay Description:Binding affinity against serine protease factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50111958(1-(4-Amino-quinazolin-7-ylmethyl)-4-(6-chloro-1H-b...)
Affinity DataKi:  3nMAssay Description:Inhibition of Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM13286(4-Hydroxy-3-[3-(S)-(7-methoxynaphthalen-2-ylsulfon...)
Affinity DataKi:  3nMAssay Description:Binding affinity against serine protease Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50123766(4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-1-(1-met...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity for human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM12595(4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-1-{[1-(2-...)
Affinity DataKi:  3nM ΔG°:  -48.2kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50123788(4-(6-Bromo-benzo[b]thiophene-2-sulfonyl)-1-(1H-pyr...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity for human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM13306(4-Hydroxy-3-[3-(S)-(5-isoxazol-3-ylthiophene-2-yls...)
Affinity DataKi:  3nMAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081517(4-Hydroxy-3-[(S)-2-oxo-3-(thieno[3,2-c]pyridine-2-...)
Affinity DataKi:  3nMAssay Description:Binding affinity against serine protease factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13286(4-Hydroxy-3-[3-(S)-(7-methoxynaphthalen-2-ylsulfon...)
Affinity DataKi:  3nM ΔG°:  -48.2kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50123782(4-(6-Chloro-thieno[2,3-b]pyridine-2-sulfonyl)-1-(1...)
Affinity DataKi:  4nMAssay Description:In vitro binding affinity for human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50123767(4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-1-(1H-py...)
Affinity DataKi:  4nMAssay Description:In vitro binding affinity for human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13283(4-amino-3-({(3S)-3-[[(7-methoxy-2-naphthyl)sulfony...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081506(3-[(S)-3-(7-Chloro-thieno[2,3-c]pyridine-2-sulfony...)
Affinity DataKi:  5nMAssay Description:Binding affinity against serine protease factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081515(4-Amino-3-[(S)-3-(5-methoxy-thieno[3,2-b]pyridine-...)
Affinity DataKi:  5nMAssay Description:Binding affinity against serine protease factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50187377(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)
Affinity DataKi:  5.10nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50187381(CHEMBL209324 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]prazosin from adrenergic alpha-1 receptor in rat cerebral cortex cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13281(4-Amino-3-[3-(S)-(7-methoxynaphthalen-2-ylsulfonyl...)
Affinity DataKi:  6nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13303(4-Amino-3-[2-oxo-3-(S)-(5-pyridin-3-ylthiophene-2-...)
Affinity DataKi:  6nMAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13281(4-Amino-3-[3-(S)-(7-methoxynaphthalen-2-ylsulfonyl...)
Affinity DataKi:  6nM ΔG°:  -46.5kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081009(CHEMBL85938 | Thieno[3,2-b]pyridine-2-sulfonic aci...)
Affinity DataKi:  6nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005127(1,1-Dioxo-2-[4-(4-pyrimidin-2-yl-piperazin-1-yl)-b...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50187387(CHEMBL210537 | N-(3-(4-(4-(4-methylphenylsulfonami...)
Affinity DataKi:  6.80nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13279(4-{[(3S)-3-[(7-methoxynaphthalene-2-)(methyl)sulfo...)
Affinity DataKi:  6.90nM ΔG°:  -46.1kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13279(4-{[(3S)-3-[(7-methoxynaphthalene-2-)(methyl)sulfo...)
Affinity DataKi:  7nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13305(4-Amino-3-[3-(S)-(5-isoxazol-3-ylthiophene-2-ylsul...)
Affinity DataKi:  7nMAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13279(4-{[(3S)-3-[(7-methoxynaphthalene-2-)(methyl)sulfo...)
Affinity DataKi:  7nMAssay Description:Compound was evaluated for the inhibition of human Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50123778(2-{2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-...)
Affinity DataKi:  8nMAssay Description:In vitro binding affinity for human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13288(Sulfonamidopyrrolidinone 27 | methyl 2-(4-carbamim...)
Affinity DataKi:  8nM ΔG°:  -45.7kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50187389(CHEMBL377697 | cyclopropanecarboxylic acid {3-[4-(...)
Affinity DataKi:  8.90nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50187379(CHEMBL379984 | N-(3-{4-[4-(2-methyl-propane-1-sulf...)
Affinity DataKi:  9.20nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50187383(CHEMBL207478 | N-[3-(4-{4-[methyl-(2-methyl-propan...)
Affinity DataKi:  9.70nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50111955(1-(4-Amino-quinazolin-7-ylmethyl)-4-(6-chloro-1H-b...)
Affinity DataKi:  10nMAssay Description:Inhibition of Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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