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TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190690(US9181233, 67)
Affinity DataKi:  10nM ΔG°:  -46.4kJ/mole IC50:  80nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM98187(US8486940, 89 | US9650362, 89)
Affinity DataKi:  12.5nM IC50:  160nMAssay Description:Spectrophotometic Assay: This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spect...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM98187(US8486940, 89 | US9650362, 89)
Affinity DataKi:  12.5nMAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometrical...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM98186(US8486940, 73 | US9650362, 73)
Affinity DataKi:  33.6nM IC50:  170nMAssay Description:Spectrophotometic Assay: This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spect...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM98186(US8486940, 73 | US9650362, 73)
Affinity DataKi:  33.6nMAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometrical...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM98182(US8486940, 14)
Affinity DataKi:  37.4nM IC50:  238nMAssay Description:Spectrophotometic Assay: This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spect...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM308046((S)-1-(1H- benzo[d]imidazol-5-yl)-5-(4- propoxyphe...)
Affinity DataKi:  37.4nMAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometrical...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190685(US9181233, 60)
Affinity DataKi:  40nM ΔG°:  -42.9kJ/mole IC50:  450nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM98183(US8486940, 43)
Affinity DataKi:  40.8nM IC50:  254nMAssay Description:Spectrophotometic Assay: This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spect...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM308047((S)-1-(1H-1,3-benzodiazol- 5-yl)-5-(4- biphenyl)im...)
Affinity DataKi:  40.8nMAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometrical...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190679(US9181233, 52)
Affinity DataKi:  50nM ΔG°:  -42.4kJ/mole IC50:  680nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM98188(US8486940, 142)
Affinity DataKi:  53.5nM IC50:  297nMAssay Description:Spectrophotometic Assay: This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spect...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM308052((S)-2-(1H-benzo[d]imidazol- 5-yl)-3-(3,4- dimethox...)
Affinity DataKi:  53.5nMAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometrical...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM98189(US8486940, 145)
Affinity DataKi:  58.8nM IC50:  240nMAssay Description:Spectrophotometic Assay: This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spect...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM308053((S)-2-(1H-benzo[d]imidazol- 5-yl)-3-(4- propoxyphe...)
Affinity DataKi:  58.8nMAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometrical...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190676(US9181233, 47)
Affinity DataKi:  60nM ΔG°:  -41.9kJ/mole IC50:  400nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190680(US9181233, 54)
Affinity DataKi:  60nM ΔG°:  -41.9kJ/mole IC50:  590nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM98180(US8486940, 12)
Affinity DataKi:  62.5nM IC50:  482nMAssay Description:Spectrophotometic Assay: This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spect...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM308044(1-(1H-benzo[d]imidazol-5- yl)-5-(4- propoxyphenyl)...)
Affinity DataKi:  62.5nMAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometrical...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM98184(US8486940, 55)
Affinity DataKi:  75nM IC50:  397nMAssay Description:Spectrophotometic Assay: This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spect...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM308048(5-(4-butoxyphenyl)-1-(H- imidazo[1,2-a]pyridin-7- ...)
Affinity DataKi:  75nMAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometrical...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190695(US9181233, 86)
Affinity DataKi:  80nM ΔG°:  -41.2kJ/mole IC50:  290nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190687(US9181233, 62)
Affinity DataKi:  80nM ΔG°:  -41.2kJ/mole IC50:  480nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190671(US9181233, 10)
Affinity DataKi:  80nM ΔG°:  -41.2kJ/mole IC50:  480nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190681(US9181233, 55)
Affinity DataKi:  80nM ΔG°:  -41.2kJ/mole IC50:  490nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190678(US9181233, 50)
Affinity DataKi:  80nM ΔG°:  -41.2kJ/mole IC50:  760nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190677(US9181233, 49)
Affinity DataKi:  90nM ΔG°:  -40.9kJ/mole IC50:  360nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190688(US9181233, 63)
Affinity DataKi:  100nM ΔG°:  -40.6kJ/mole IC50:  220nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190694(US9181233, 85)
Affinity DataKi:  100nM ΔG°:  -40.6kJ/mole IC50:  470nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190669(US9181233, 8)
Affinity DataKi:  110nM ΔG°:  -40.4kJ/mole IC50:  640nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190672(US9181233, 22)
Affinity DataKi:  120nM ΔG°:  -40.2kJ/mole IC50:  520nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190689(US9181233, 65)
Affinity DataKi:  120nM ΔG°:  -40.2kJ/mole IC50:  530nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190696(US9181233, 87)
Affinity DataKi:  120nM ΔG°:  -40.2kJ/mole IC50:  550nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190684(US9181233, 59)
Affinity DataKi:  120nM ΔG°:  -40.2kJ/mole IC50:  560nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190693(US9181233, 84)
Affinity DataKi:  120nM ΔG°:  -40.2kJ/mole IC50:  570nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190674(US9181233, 39)
Affinity DataKi:  130nM ΔG°:  -40.0kJ/mole IC50:  800nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190682(US9181233, 57)
Affinity DataKi:  130nM ΔG°:  -40.0kJ/mole IC50:  830nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190692(US9181233, 83)
Affinity DataKi:  140nM ΔG°:  -39.8kJ/mole IC50:  570nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190683(US9181233, 58)
Affinity DataKi:  140nM ΔG°:  -39.8kJ/mole IC50:  720nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM98185(US8486940, 60 | US9650362, 60)
Affinity DataKi:  149nM IC50:  882nMAssay Description:Spectrophotometic Assay: This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spect...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM98185(US8486940, 60 | US9650362, 60)
Affinity DataKi:  149nMAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometrical...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190691(US9181233, 68)
Affinity DataKi:  150nM ΔG°:  -39.6kJ/mole IC50:  410nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190686(US9181233, 61)
Affinity DataKi:  170nM ΔG°:  -39.3kJ/mole IC50:  760nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190675(US9181233, 46)
Affinity DataKi:  180nM ΔG°:  -39.1kJ/mole IC50:  640nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM102923(US8541596, 54)
Affinity DataKi:  194nM IC50:  2.65E+3nMAssay Description:Spectrophotometric assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190670(US9181233, 9)
Affinity DataKi:  200nM ΔG°:  -38.9kJ/mole IC50:  760nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM102924(US8541596, 55)
Affinity DataKi:  228nM IC50:  3.71E+3nMAssay Description:Spectrophotometric assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM190673(US9181233, 24)
Affinity DataKi:  230nM ΔG°:  -38.5kJ/mole IC50:  850nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM102925(US8541596, 56)
Affinity DataKi:  271nM IC50:  4.12E+3nMAssay Description:Spectrophotometric assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM102922(US8541596, 52)
Affinity DataKi:  305nM IC50:  3.06E+3nMAssay Description:Spectrophotometric assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically...More data for this Ligand-Target Pair
In DepthDetails US Patent
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