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Found 394 with Last Name = 'chai' and Initial = 'cl'
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50086884((R)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-9-oxo-1,8-di...)
Affinity DataKi:  1nMAssay Description:binding affinity towards HIV-1 Protease enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50086880(Proteolytic Enzyme inhibitor)
Affinity DataKi:  1nMAssay Description:binding affinity towards HIV-1 Protease enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50369797(CHEMBL1794029)
Affinity DataKi:  3nMAssay Description:binding affinity towards HIV-1 Protease enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50369799(CHEMBL1794024)
Affinity DataKi:  4nMAssay Description:binding affinity towards HIV-1 Protease enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50086886(CHEMBL436149 | N-[14-Benzyl-18-(3-guanidino-propyl...)
Affinity DataKi:  10nMAssay Description:binding affinity towards HIV-1 Protease enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50086883(2-{2-[2-(8-Carbamoylmethyl-6,9-dioxo-2-oxa-7,10-di...)
Affinity DataKi:  12nMAssay Description:binding affinity towards HIV-1 Protease enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
A* Star

Curated by ChEMBL
LigandPNGBDBM50075951(CHEMBL3415810)
Affinity DataKi:  60nMAssay Description:Binding affinity to human recombinant MAO-B measured after longer preincubationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50369800(CHEMBL1232357)
Affinity DataKi:  800nMAssay Description:binding affinity towards HIV-1 Protease enzymeMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM50308110((S,Z)-2-(5-((6-(2,3-dimethoxyphenyl)pyridin-3-yl)m...)
Affinity DataKi:  3.40E+3nMAssay Description:Binding affinity to human Bcl-XL by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM50308110((S,Z)-2-(5-((6-(2,3-dimethoxyphenyl)pyridin-3-yl)m...)
Affinity DataKi:  3.70E+3nMAssay Description:Displacement of fluorescein-labeled Bak-BH3 peptide from human Bcl-XL by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM50107130((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...)
Affinity DataKi:  8.70E+3nMAssay Description:Binding affinity to human Bcl-XL by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM50107130((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of fluorescein-labeled Bak-BH3 peptide from human Bcl-XL by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50369798(CHEMBL1794028)
Affinity DataKi:  6.00E+4nMAssay Description:binding affinity towards HIV-1 Protease enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM50308111((S,Z)-2-(5-((6-(3,4-dimethoxyphenyl)pyridin-3-yl)m...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of fluorescein-labeled Bak-BH3 peptide from human Bcl-XL by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM50308111((S,Z)-2-(5-((6-(3,4-dimethoxyphenyl)pyridin-3-yl)m...)
Affinity DataKi: >7.50E+5nMAssay Description:Binding affinity to human Bcl-XL by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
A* Star

Curated by ChEMBL
LigandPNGBDBM50075952(CHEMBL3415804)
Affinity DataIC50:  0.720nMAssay Description:Inhibition of human recombinant MAO-A expressed in Sf9 cells using 5-hydroxytryptamine substrate assessed as hydrogen peroxide production after 1 hr ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
A* Star

Curated by ChEMBL
LigandPNGBDBM50075959(CHEMBL3415795)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of human recombinant MAO-A expressed in Sf9 cells using 5-hydroxytryptamine substrate assessed as hydrogen peroxide production after 1 hr ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
A* Star

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)
Affinity DataIC50:  1nMAssay Description:Inhibition of rat brain MAO-A in nuclei-free homogenates using [14C]hydroxytryptamine substrate after 20 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
A* Star

Curated by ChEMBL
LigandPNGBDBM50075947(CHEMBL3415817)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant MAO-A expressed in Sf9 cells using 5-hydroxytryptamine substrate assessed as hydrogen peroxide production after 1 hr ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
A* Star

Curated by ChEMBL
LigandPNGBDBM50075974(CHEMBL3415783)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human recombinant MAO-A expressed in Sf9 cells using 5-hydroxytryptamine substrate assessed as hydrogen peroxide production after 1 hr ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
A* Star

Curated by ChEMBL
LigandPNGBDBM50075965(CHEMBL3415613)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of rat brain MAO-A in nuclei-free homogenates using [14C]hydroxytryptamine substrate after 20 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
A* Star

Curated by ChEMBL
LigandPNGBDBM50075996(CHEMBL3415611)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human recombinant MAO-A expressed in Sf9 cells using 5-hydroxytryptamine substrate assessed as hydrogen peroxide production after 1 hr ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
A* Star

Curated by ChEMBL
LigandPNGBDBM50075969(CHEMBL3415617)
Affinity DataIC50:  2nMAssay Description:Inhibition of rat brain MAO-A in nuclei-free homogenates using [14C]hydroxytryptamine substrate after 20 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
A* Star

Curated by ChEMBL
LigandPNGBDBM50075946(CHEMBL3415816)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human recombinant MAO-A expressed in Sf9 cells using 5-hydroxytryptamine substrate assessed as hydrogen peroxide production after 1 hr ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM476189(US10865384, Compound IM-39 | US10865384, Example 2...)
Affinity DataIC50:  2.70nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter™ p38 MAP kinase binding assay from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM476192(US10865384, Compound IM-34 | US10865384, Example 2...)
Affinity DataIC50:  2.80nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter™ p38 MAP kinase binding assay from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM476187(US10865384, Compound IM-37 | US10865384, Example 2...)
Affinity DataIC50:  3.20nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter™ p38 MAP kinase binding assay from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM476188(US10865384, Compound IM-38 | US10865384, Example 2...)
Affinity DataIC50:  3.30nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter™ p38 MAP kinase binding assay from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
A* Star

Curated by ChEMBL
LigandPNGBDBM50075953(CHEMBL3415805)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human recombinant MAO-A expressed in Sf9 cells using 5-hydroxytryptamine substrate assessed as hydrogen peroxide production after 1 hr ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM476190(US10865384, Compound IM-40 | US10865384, Example 2...)
Affinity DataIC50:  3.70nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter™ p38 MAP kinase binding assay from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
A* Star

Curated by ChEMBL
LigandPNGBDBM50075961(CHEMBL3415798)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human recombinant MAO-A expressed in Sf9 cells using 5-hydroxytryptamine substrate assessed as hydrogen peroxide production after 1 hr ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
A* Star

Curated by ChEMBL
LigandPNGBDBM50075958(CHEMBL3415793)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of human recombinant MAO-A expressed in Sf9 cells using 5-hydroxytryptamine substrate assessed as hydrogen peroxide production after 1 hr ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
A* Star

Curated by ChEMBL
LigandPNGBDBM50075949(CHEMBL3415819)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of human recombinant MAO-A expressed in Sf9 cells using 5-hydroxytryptamine substrate assessed as hydrogen peroxide production after 1 hr ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM50491733(CHEMBL2385554 | US10865384, Compound IM-26)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of recombinant GST-tagged p38alpha MAP kinase (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM50491733(CHEMBL2385554 | US10865384, Compound IM-26)
Affinity DataIC50:  4.30nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter™ p38 MAP kinase binding assay from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM476191(US10865384, Compound IM-32 | US10865384, Example 2...)
Affinity DataIC50:  4.40nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter™ p38 MAP kinase binding assay from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM50491730(CHEMBL2385555 | US10865384, Compound IM-19)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of recombinant GST-tagged p38alpha MAP kinase (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM50491730(CHEMBL2385555 | US10865384, Compound IM-19)
Affinity DataIC50:  4.70nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter™ p38 MAP kinase binding assay from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM476185(US10865384, Compound IM-35 | US10865384, Example 2...)
Affinity DataIC50:  5nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter™ p38 MAP kinase binding assay from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM476186(US10865384, Compound IM-36 | US10865384, Example 2...)
Affinity DataIC50:  5.30nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter™ p38 MAP kinase binding assay from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
A* Star

Curated by ChEMBL
LigandPNGBDBM50075974(CHEMBL3415783)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of human recombinant MAO-B expressed in Sf9 cells using 5-phenylacetaldehyde substrate assessed as hydrogen peroxide production after 1 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
A* Star

Curated by ChEMBL
LigandPNGBDBM50075994(CHEMBL3415785)
Affinity DataIC50:  6nMAssay Description:Inhibition of rat brain MAO-A in nuclei-free homogenates using [14C]hydroxytryptamine substrate after 20 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
A* Star

Curated by ChEMBL
LigandPNGBDBM50075964(CHEMBL3415802)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant MAO-A expressed in Sf9 cells using 5-hydroxytryptamine substrate assessed as hydrogen peroxide production after 1 hr ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
A* Star

Curated by ChEMBL
LigandPNGBDBM50075950(CHEMBL3415820)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of human recombinant MAO-A expressed in Sf9 cells using 5-hydroxytryptamine substrate assessed as hydrogen peroxide production after 1 hr ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
A* Star

Curated by ChEMBL
LigandPNGBDBM50075995(CHEMBL3415786)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of human recombinant MAO-A expressed in Sf9 cells using 5-hydroxytryptamine substrate assessed as hydrogen peroxide production after 1 hr ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM476175(US10865384, Compound IM-31 | US10865384, Example 1...)
Affinity DataIC50:  6.40nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter™ p38 MAP kinase binding assay from ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM476175(US10865384, Compound IM-31 | US10865384, Example 1...)
Affinity DataIC50:  6.40nMAssay Description:Table 3: Small molecules were tested for their inhibitory activities towards casein kinase 1 delta (CK1δ) and 1 epsilon (CK1ϵ). The in vit...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
A* Star

Curated by ChEMBL
LigandPNGBDBM50075971(CHEMBL3415780)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of human recombinant MAO-A expressed in Sf9 cells using 5-hydroxytryptamine substrate assessed as hydrogen peroxide production after 1 hr ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM476175(US10865384, Compound IM-31 | US10865384, Example 1...)
Affinity DataIC50:  6.70nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter™ p38 MAP kinase binding assay from ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM476175(US10865384, Compound IM-31 | US10865384, Example 1...)
Affinity DataIC50:  6.80nMAssay Description:Table 3: Small molecules were tested for their inhibitory activities towards casein kinase 1 delta (CK1δ) and 1 epsilon (CK1ϵ). The in vit...More data for this Ligand-Target Pair
In DepthDetails US Patent
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