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Found 505 with Last Name = 'dol' and Initial = 'f'
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50049750((S)-3-(azetidin-2-ylmethoxy)pyridine | 3-((S)-1-Az...)
Affinity DataKi:  0.0500nMAssay Description:Binding affinity of the compound against human Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50210860(CHEMBL3936390)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat heart membranes after 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50210866(CHEMBL3979767)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat heart membranes after 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50159018(1-Benzyl-4-chroman-2-ylmethyl-piperazine | 1-benzy...)
Affinity DataKi:  0.300nMAssay Description:Inhibitory constant against sigma receptor type 1 using 3 nM [3H]pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50159021(1-Benzyl-4-chroman-3-ylmethyl-piperazine | 1-benzy...)
Affinity DataKi:  0.300nMAssay Description:Inhibitory constant against sigma receptor type 1 using 3 nM [3H]pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50159013(3-(4-Benzyl-piperazin-1-ylmethyl)-3,4-dihydro-2H-n...)
Affinity DataKi:  0.300nMAssay Description:Inhibitory constant against sigma receptor type 1 using 3 nM [3H]pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50117259(CHEMBL3613363)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]-PK11195 from rat heart membrane TSPOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50210858(CHEMBL3906952)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat heart membranes after 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50005293(CHEMBL3125363)
Affinity DataKi:  0.350nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat heart membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50243008(CHEMBL469682 | N,N-Diethyl-2-(2-(4-(3-fluoropropox...)
Affinity DataKi:  0.370nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat heart membranes after 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50117212(CHEMBL3613360)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-PK11195 from rat heart membrane TSPOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50159009(2-(4-Benzyl-piperazin-1-ylmethyl)-3,4-dihydro-2H-n...)
Affinity DataKi:  0.400nMAssay Description:Inhibitory constant against sigma receptor type 1 using 3 nM [3H]pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Sanofi-Aventis R&D

Curated by ChEMBL
LigandPNGBDBM7840(RIVAROXABAN | US8822458, 44 | US8822458, 97)
Affinity DataKi:  0.400nMAssay Description:Inhibition of factor-10a (unknown origin)More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Affinity DataKi:  0.420nMAssay Description:Inhibitory constant against dopamine D2 receptor using 0.2 nM [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50117211(CHEMBL3613361)
Affinity DataKi:  0.420nMAssay Description:Displacement of [3H]-PK11195 from rat heart membrane TSPOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50350912(CHEMBL1817978)
Affinity DataKi:  0.440nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat heart membrane homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50159011(4-Benzyl-1-(4-phenyl-butyl)-piperidine | CHEMBL178...)
Affinity DataKi:  0.490nMAssay Description:Inhibitory constant against sigma receptor type 2 using 3 nM [3H]ditolylguanidineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50178936(2-(2-((dimethylamino)methyl)phenoxy)-5-methylbenze...)
Affinity DataKi:  0.530nMAssay Description:Displacement of [3H]paroxetine from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50005295(CHEMBL3125361)
Affinity DataKi:  0.540nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat heart membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM86708(CAS_146714-97-8 | CHEMBL31354 | CHEMBL514874 | CHE...)
Affinity DataKi:  0.600nMAssay Description:Inhibitory constant was determined against 5-hydroxytryptamine 1A receptor using 1.2 nM [3H]8-OH-DPATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50117258(CHEMBL3613358)
Affinity DataKi:  0.680nMAssay Description:Displacement of [3H]-PK11195 from rat heart membrane TSPOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50005294(CHEMBL3125362)
Affinity DataKi:  0.740nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat heart membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50005292(CHEMBL3125364)
Affinity DataKi:  0.790nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat heart membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50159028(1-Benzyl-4-(1,2,3,4-tetrahydro-naphthalen-2-ylmeth...)
Affinity DataKi:  0.800nMAssay Description:Inhibitory constant against sigma receptor type 1 using 3 nM [3H]pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50255226((7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihyd...)
Affinity DataKi:  0.830nMAssay Description:Displacement of [3H]-PK11195 from rat heart membrane TSPOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50243007(2-(2-(4-(2-Fluoroethoxy)phenyl)-5,7-dimethylpyrazo...)
Affinity DataKi:  0.910nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat heart membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50243007(2-(2-(4-(2-Fluoroethoxy)phenyl)-5,7-dimethylpyrazo...)
Affinity DataKi:  0.910nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat heart membranes after 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50117265(CHEMBL3613362)
Affinity DataKi:  0.960nMAssay Description:Displacement of [3H]-PK11195 from rat heart membrane TSPOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Sanofi-Aventis R&D

Curated by ChEMBL
LigandPNGBDBM50443853(CHEMBL3091519 | US20230391761, Reference 1)
Affinity DataKi:  1nMAssay Description:Inhibition of human coagulation factor 10a using S-2765 as substrate measured up to 20 mins by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50327234(2-[2-(4'-Butoxy1phenyl)-5,7-dimethylpyrazolo[1,5-a...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50210857(CHEMBL3938340)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat heart membranes after 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50350912(CHEMBL1817978)
Affinity DataKi:  1.19nMAssay Description:Displacement of [3H]PK11195 from TSPO in human HEK293 mitochondrial fractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50210864(CHEMBL3960249)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat heart membranes after 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50159023(2-(4-Benzyl-piperazin-1-ylmethyl)-chroman-4-one | ...)
Affinity DataKi:  1.20nMAssay Description:Inhibitory constant against sigma receptor type 1 using 3 nM [3H]pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50327236(2-[5,7-Dimethyl-2-(4'-propoxyphenyl)pyrazolo[1,5-a...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50117210(CHEMBL3613359)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]-PK11195 from rat heart membrane TSPOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50159011(4-Benzyl-1-(4-phenyl-butyl)-piperidine | CHEMBL178...)
Affinity DataKi:  1.40nMAssay Description:Inhibitory constant against sigma receptor type 1 using 3 nM [3H]pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50159029(3-(4-Benzyl-piperidin-1-ylmethyl)-3,4-dihydro-2H-n...)
Affinity DataKi:  1.40nMAssay Description:Inhibitory constant against sigma receptor type 1 using 3 nM [3H]pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50159014(4-Benzyl-1-indan-2-ylmethyl-piperidine | CHEMBL179...)
Affinity DataKi:  1.40nMAssay Description:Inhibitory constant against sigma receptor type 1 using 3 nM [3H]pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50159033(2-(4-Benzyl-piperidin-1-ylmethyl)-chroman-4-one | ...)
Affinity DataKi:  1.40nMAssay Description:Inhibitory constant against sigma receptor type 1 using 3 nM [3H]pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50159009(2-(4-Benzyl-piperazin-1-ylmethyl)-3,4-dihydro-2H-n...)
Affinity DataKi:  1.40nMAssay Description:Inhibitory constant against sigma receptor type 2 using 3 nM [3H]ditolylguanidineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50159021(1-Benzyl-4-chroman-3-ylmethyl-piperazine | 1-benzy...)
Affinity DataKi:  1.48nMAssay Description:Inhibitory constant against sigma receptor type 2 using 3 nM [3H]ditolylguanidineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50159020(4-Benzyl-1-(1,2,3,4-tetrahydro-naphthalen-2-ylmeth...)
Affinity DataKi:  1.5nMAssay Description:Inhibitory constant against sigma receptor type 1 using 3 nM [3H]pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50117266(CHEMBL3613365)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-PK11195 from rat heart membrane TSPOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50159013(3-(4-Benzyl-piperazin-1-ylmethyl)-3,4-dihydro-2H-n...)
Affinity DataKi:  1.59nMAssay Description:Inhibitory constant against sigma receptor type 2 using 3 nM [3H]ditolylguanidineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50110788(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)
Affinity DataKi:  1.65nMAssay Description:Displacement of [3H]paroxetine from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50159028(1-Benzyl-4-(1,2,3,4-tetrahydro-naphthalen-2-ylmeth...)
Affinity DataKi:  1.70nMAssay Description:Inhibitory constant against sigma receptor type 2 using 3 nM [3H]ditolylguanidineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM22032(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat heart membrane homogenateMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
Institute Of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50210867(CHEMBL3923539)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat heart membranes after 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  2.20nMAssay Description:Inhibitory constant against sigma receptor type 1 using 3 nM [3H]pentazocineMore data for this Ligand-Target Pair
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