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Found 1676 with Last Name = 'edwards' and Initial = 'd'
LigandPNGBDBM50573166(CHEMBL4869783)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50573157(CHEMBL4850297)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50573177(CHEMBL4167702)
Affinity DataKi:  0.0126nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
LigandPNGBDBM50573167(CHEMBL4858875)
Affinity DataKi:  0.0158nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50573181(CHEMBL4165185)
Affinity DataKi:  0.0251nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50573182(CHEMBL4175571)
Affinity DataKi:  0.0251nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50573164(CHEMBL4873390)
Affinity DataKi:  0.0251nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50573180(CHEMBL4175737)
Affinity DataKi:  0.0316nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50573175(CHEMBL4169192)
Affinity DataKi:  0.0398nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50573176(CHEMBL4173087)
Affinity DataKi:  0.0501nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50573179(CHEMBL4174874)
Affinity DataKi:  0.0501nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091753(CHEMBL405854 | H-Ser-Leu-Arg-Arg-Ser-Ser-cyclic(Cy...)
Affinity DataKi:  0.0590nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061031((S)-1-[(S)-2-(4-Benzenesulfonylaminocarbonyl-benzo...)
Affinity DataKi:  0.0600nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031196(2-[3-Methyl-2-({1-[3-methyl-2-(4-chlorophenyl-sulf...)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50573178(CHEMBL4170075)
Affinity DataKi:  0.0631nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50573170(CHEMBL4855234)
Affinity DataKi:  0.0794nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031185(2-{(S)-2-[((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfon...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091751(CHEMBL411542 | Cyclic-(Cys-Phe-Gly-Gly-Arg-Ile-Asp...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091751(CHEMBL411542 | Cyclic-(Cys-Phe-Gly-Gly-Arg-Ile-Asp...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50573159(CHEMBL4867203)
Affinity DataKi:  0.126nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031203(2-{(S)-2-[((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfon...)
Affinity DataKi:  0.180nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031187(2-{(S)-2-[((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfon...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031198(1-(4-(((S)-1-((S)-2-(((S)-1-(benzo[d]oxazol-2-yl)-...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50496270(CHEMBL3127679)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human histamine H3 receptor expressed in CHOK1 cells after 1.5 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50130561((R)-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dime...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091758((S)-N-[(S)-4-Guanidino-1-((S)-2-methyl-butylcarbam...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091758((S)-N-[(S)-4-Guanidino-1-((S)-2-methyl-butylcarbam...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031188(2-[(S)-3-Methyl-2-({(S)-1-[(S)-3-methyl-2-(4-trifl...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50072775(2-((1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohe...)
Affinity DataKi:  0.316nMAssay Description:Displacement of [3H]CP55940 from human cannabinoid CB1 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50072775(2-((1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohe...)
Affinity DataKi:  0.316nMAssay Description:Displacement of [3H]CP55940 from human cannabinoid CB2 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031209((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarb...)
Affinity DataKi:  0.330nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031217(CHEMBL262516 | N-((S)-1-{(S)-2-[(S)-1-(Benzooxazol...)
Affinity DataKi:  0.340nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061028((S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-but...)
Affinity DataKi:  0.350nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031197(2-[(S)-3-Methyl-2-({(S)-1-[(S)-3-methyl-2-(4-sulfa...)
Affinity DataKi:  0.350nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061047(((S)-2,2-Difluoro-5-methyl-4-{[(S)-1-((S)-3-methyl...)
Affinity DataKi:  0.350nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061043(CHEMBL106592 | [(S)-1-((S)-2-{(S)-3,3-Difluoro-1-i...)
Affinity DataKi:  0.350nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031210(2-((S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-3-m...)
Affinity DataKi:  0.370nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061037(CHEMBL302961 | {(S)-1-[(S)-2-((S)-3-Carbamoyl-3,3-...)
Affinity DataKi:  0.380nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50416474(CHEMBL1209710)
Affinity DataKi:  0.398nMAssay Description:Displacement of [3H]CP-55940 from human cannabinoid CB2 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50418229(CHEMBL1760646)
Affinity DataKi:  0.398nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036037(CHEMBL165759 | {(S)-1-[(S)-2-((S)-3-Benzylcarbamoy...)
Affinity DataKi:  0.400nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE) catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala- Ala-Pro-Val-pNMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091752((S)-3-{(2S,3S)-2-[(S)-5-Guanidino-2-(2-{4-[(naphth...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091752((S)-3-{(2S,3S)-2-[(S)-5-Guanidino-2-(2-{4-[(naphth...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058357(1-[(S)-3-Methyl-2-(4-phenoxy-benzoylamino)-butyryl...)
Affinity DataKi:  0.410nMAssay Description:Inhibitory activity against Human Neutrophil Elastase using acute lung injury model (ALIM) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058376(4-((E)-2-{(S)-2-Methyl-1-[2-(3,3,3-trifluoro-1-iso...)
Affinity DataKi:  0.430nMAssay Description:Inhibitory activity against Human Neutrophil Elastase using acute lung injury model (ALIM) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031192(CHEMBL339650 | [(S)-1-((S)-2-{(S)-1-[5-(tert-Butyl...)
Affinity DataKi:  0.430nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091761((S)-N-[(S)-4-Guanidino-1-((S)-2-methyl-butylcarbam...)
Affinity DataKi:  0.480nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091757(CHEMBL264744 | Cyclic-(Cys-Phe-Gly-Gly-Ala-Ile-Asp...)
Affinity DataKi:  0.490nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091757(CHEMBL264744 | Cyclic-(Cys-Phe-Gly-Gly-Ala-Ile-Asp...)
Affinity DataKi:  0.490nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031194((S)-1-[(S)-2-(4-Benzenesulfonylaminocarbonyl-benzo...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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