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Found 51 with Last Name = 'fairweather' and Initial = 'n'
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13433(N-[(3S)-2-[(tert-butoxy)carbonyl]-3-(methylcarbamo...)
Affinity DataKi:  2.40E+4nM ΔG°:  -26.1kJ/molepH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13529(N-(1-methyl-3-phenyl-1H-pyrazol-5-yl)sulfamic acid...)
Affinity DataKi: >5.00E+5nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189954(2-(3,4-dimethylphenyl)-3-(2-(4-methoxycyclohexa-2,...)
Affinity DataIC50:  137nMAssay Description:Blockade of Kv1.5 channel expressed in LTK cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase(Escherichia coli (strain K12))
The Procter & Gamble Pharmaceuticals

LigandPNGBDBM17853(3,5-Pyrazolediamine Inhibitor, 3 | 3-imino-4-[(E)-...)
Affinity DataIC50:  250nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMethionine aminopeptidase(Escherichia coli (strain K12))
The Procter & Gamble Pharmaceuticals

LigandPNGBDBM17854(3,5-Pyrazolediamine Inhibitor, 4 | 3-imino-4-[(E)-...)
Affinity DataIC50:  250nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189955((2-(4-methoxyphenethyl)-2H-1,2,3-triazol-4-yl)(3,4...)
Affinity DataIC50:  294nMAssay Description:Blockade of Kv1.5 channel expressed in LTK cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase(Escherichia coli (strain K12))
The Procter & Gamble Pharmaceuticals

LigandPNGBDBM17855(3,5-Pyrazolediamine Inhibitor, 5 | 4-[(E)-2-(3-flu...)
Affinity DataIC50:  550nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase(Escherichia coli (strain K12))
The Procter & Gamble Pharmaceuticals

LigandPNGBDBM17856(3,5-Pyrazolediamine Inhibitor, 6 | 4-[(E)-2-(3-chl...)
Affinity DataIC50:  550nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase(Escherichia coli (strain K12))
The Procter & Gamble Pharmaceuticals

LigandPNGBDBM17857(3,5-Pyrazolediamine Inhibitor, 7 | 4-[(E)-2-(4-flu...)
Affinity DataIC50:  580nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...More data for this Ligand-Target Pair
TargetMethionine aminopeptidase(Escherichia coli (strain K12))
The Procter & Gamble Pharmaceuticals

LigandPNGBDBM17858(3,5-Pyrazolediamine Inhibitor, 8 | 4-[(E)-2-(4-chl...)
Affinity DataIC50:  1.25E+3nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase(Escherichia coli (strain K12))
The Procter & Gamble Pharmaceuticals

LigandPNGBDBM17859(3,5-Pyrazolediamine Inhibitor, 9 | 3-imino-4-[(E)-...)
Affinity DataIC50:  1.50E+3nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase(Escherichia coli (strain K12))
The Procter & Gamble Pharmaceuticals

LigandPNGBDBM17863(Amino-Alcohol Inhibitor, 12 | methyl 2-[(2S)-2-[(2...)
Affinity DataIC50:  1.70E+3nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...More data for this Ligand-Target Pair
TargetMethionine aminopeptidase(Escherichia coli (strain K12))
The Procter & Gamble Pharmaceuticals

LigandPNGBDBM17860(3,5-Pyrazolediamine Inhibitor, 2 | 3-[(E)-2-(5-ami...)
Affinity DataIC50:  1.75E+3nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...More data for this Ligand-Target Pair
TargetMethionine aminopeptidase(Escherichia coli (strain K12))
The Procter & Gamble Pharmaceuticals

LigandPNGBDBM17861(3,5-Pyrazolediamine Inhibitor, 10 | 3-[(E)-2-(5-am...)
Affinity DataIC50:  2.00E+3nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13462(3-{3-[(3S)-3-(methylcarbamoyl)-7-(sulfoamino)-1,2,...)
Affinity DataIC50:  2.50E+3nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
TargetMethionine aminopeptidase(Escherichia coli (strain K12))
The Procter & Gamble Pharmaceuticals

LigandPNGBDBM17864(Amino-Alcohol Inhibitor, 13 | methyl (2S)-2-[(2S)-...)
Affinity DataIC50:  3.50E+3nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13461(N-[(3S)-3-(methylcarbamoyl)-2-{3-[3-(sulfoamino)ph...)
Affinity DataIC50:  4.80E+3nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13452(N-[(3S)-2-[(tert-butoxy)carbonyl]-3-(3-methyl-1,2,...)
Affinity DataIC50:  8.23E+3nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase(Escherichia coli (strain K12))
The Procter & Gamble Pharmaceuticals

LigandPNGBDBM17865(Amino-Alcohol Inhibitor, 14 | methyl (2S)-2-[(2S)-...)
Affinity DataIC50:  1.20E+4nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13451(N-[(3S)-2-[(tert-butoxy)carbonyl]-3-[(2-methylprop...)
Affinity DataIC50:  1.67E+4nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13450(N-[(3S)-2-[(tert-butoxy)carbonyl]-3-(methoxycarbon...)
Affinity DataIC50:  1.90E+4nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase(Escherichia coli (strain K12))
The Procter & Gamble Pharmaceuticals

LigandPNGBDBM17862(({4-[(E)-2-(5-amino-3-imino-3H-pyrazol-4-yl)diazen...)
Affinity DataIC50:  2.00E+4nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13446(Tetrahydroisoquinoline (TIQ) deriv. 8m | ammonium ...)
Affinity DataIC50:  2.49E+4nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase(Escherichia coli (strain K12))
The Procter & Gamble Pharmaceuticals

LigandPNGBDBM17866(Amino-Alcohol Inhibitor, 15 | methyl (2S)-2-[(2S)-...)
Affinity DataIC50:  2.50E+4nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13464(N-(3-{3-oxo-3-[7-(sulfoamino)-1,2,3,4-tetrahydrois...)
Affinity DataIC50:  2.60E+4nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13463(N-{3-[2-({[3-(sulfoamino)phenyl]methyl}carbamoyl)e...)
Affinity DataIC50:  3.35E+4nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13445(Tetrahydroisoquinoline (TIQ) deriv. 8l | ammonium ...)
Affinity DataIC50:  3.67E+4nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13444(Tetrahydroisoquinoline (TIQ) deriv. 8k | ammonium ...)
Affinity DataIC50:  3.70E+4nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13431(CHEMBL204336 | N-{4-[(2S)-2-{[(tert-butoxy)carbony...)
Affinity DataIC50:  3.96E+4nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13433(N-[(3S)-2-[(tert-butoxy)carbonyl]-3-(methylcarbamo...)
Affinity DataIC50:  4.25E+4nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13449(N-[(3S)-2-[(tert-butoxy)carbonyl]-3-[(2-phenylethy...)
Affinity DataIC50:  5.14E+4nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13443(Tetrahydroisoquinoline (TIQ) deriv. 8j | ammonium ...)
Affinity DataIC50:  6.44E+4nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13460(N-[(3S)-2-[3-(3-hydroxyphenyl)propanoyl]-3-(methyl...)
Affinity DataIC50:  8.21E+4nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13442(Tetrahydroisoquinoline (TIQ) deriv. 8i | ammonium ...)
Affinity DataIC50:  8.36E+4nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13459(N-[(3S)-2-{2-[3-hydroxy-2-(methoxycarbonyl)phenoxy...)
Affinity DataIC50:  9.34E+4nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13441(Tetrahydroisoquinoline (TIQ) deriv. 8h | ammonium ...)
Affinity DataIC50:  9.53E+4nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13458(N-[(3S)-2-[3-(3-chlorophenyl)propanoyl]-3-(methylc...)
Affinity DataIC50:  1.01E+5nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13448(N-[(3S)-3-(benzylcarbamoyl)-2-[(tert-butoxy)carbon...)
Affinity DataIC50:  1.20E+5nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13440(Tetrahydroisoquinoline (TIQ) deriv. 8g | ammonium ...)
Affinity DataIC50:  1.35E+5nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13457(N-[(3S)-3-(methylcarbamoyl)-2-{3-[3-(trifluorometh...)
Affinity DataIC50:  1.46E+5nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13439(Tetrahydroisoquinoline (TIQ) deriv. 8f | ammonium ...)
Affinity DataIC50:  1.48E+5nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13438(Tetrahydroisoquinoline (TIQ) deriv. 8e | ammonium ...)
Affinity DataIC50:  1.54E+5nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13437(Tetrahydroisoquinoline (TIQ) deriv. 8d | ammonium ...)
Affinity DataIC50:  1.64E+5nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13456(N-[(3S)-2-{3-[3-methanesulfonamido-5-(trifluoromet...)
Affinity DataIC50:  1.84E+5nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13455(N-[(3S)-3-(methylcarbamoyl)-2-[3-(4-methylphenyl)p...)
Affinity DataIC50:  1.98E+5nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13454(N-[(3S)-3-(methylcarbamoyl)-2-{3-[4-(trifluorometh...)
Affinity DataIC50:  2.25E+5nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13453(N-[(3S)-2-[3-(4-methoxyphenyl)propanoyl]-3-(methyl...)
Affinity DataIC50:  2.42E+5nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13436(Tetrahydroisoquinoline (TIQ) deriv. 8c | ammonium ...)
Affinity DataIC50:  2.71E+5nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13435(Tetrahydroisoquinoline (TIQ) deriv. 8b | ammonium ...)
Affinity DataIC50:  2.86E+5nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13434(Tetrahydroisoquinoline (TIQ) deriv. 8a | ammonium ...)
Affinity DataIC50: >5.00E+5nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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