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Found 978 with Last Name = 'garcia' and Initial = 'y'
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM50575884(CHEMBL4849371)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50152667(CHEMBL3780636)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50521218(CHEMBL4434674)
Affinity DataIC50:  0.330nMAssay Description:Inhibition of PI3KD (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50152602(CHEMBL3781442)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50575901(CHEMBL4878995)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataIC50:  0.430nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM333988((S)-1-(3-((9-ethyl-8-(6-methoxy- 5-methylpyridin-3...)
Affinity DataIC50:  0.5nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50512300(CHEMBL4575012)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM333882(US9730940, Compound 1-35 | tert-butyl (3S)-3-{[8-(...)
Affinity DataIC50:  0.5nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50152666(CHEMBL3781359)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50570784(CHEMBL4873442)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50570790(CHEMBL4847971)
Affinity DataIC50:  0.540nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM333992((S)-1-(3-((9-ethyl-8-(1-ethyl-5- methyl-1H-pyrazol...)
Affinity DataIC50:  0.600nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50152668(CHEMBL3779913)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50575891(CHEMBL4852541)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM333881(US9730940, Compound 1-34 | tert-butyl (3S)-3-{[9-e...)
Affinity DataIC50:  0.700nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50152665(CHEMBL3781394)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50575907(CHEMBL4878004)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50570788(CHEMBL4877330)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataIC50:  0.720nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50570783(CHEMBL4878320)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50152607(CHEMBL3780230)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50152601(CHEMBL3780467)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50575903(CHEMBL4858121)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50152603(CHEMBL3780299)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50512313(CHEMBL4435694)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50570789(CHEMBL4852562)
Affinity DataIC50:  0.940nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM334115(9-ethyl-8-(5-fluoro-6- methoxypyridin-3-yl)-6-{[(3...)
Affinity DataIC50: <1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM334113(9-ethyl-8-(5-fluoro-6- methoxypyridin-3-yl)-6-{[(3...)
Affinity DataIC50: <1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM334177((S)-(3-((9-ethyl-8-(6- (trifluoromethyl)pyridin-3-...)
Affinity DataIC50: <1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM334026(6-({(3S)-1-[S- or R-(2,2- dimethylcyclopropyl)carb...)
Affinity DataIC50:  1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM334126((S)-(3-((9-ethyl-8-(1-ethyl-5- methyl-1H-pyrazol-4...)
Affinity DataIC50: <1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM334021(9-ethyl-8-(2-methylpyrimidin-5- yl)-6-{[(3S)-1-((R...)
Affinity DataIC50: <1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM334122(9-ethyl-6-{[(3S)-1-(2- methylpropanoyl)pyrrolidin-...)
Affinity DataIC50: <1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM334085(8-(5-chloro-6-methoxypyridin- 3-yl)-6-{[(3S)-1- (c...)
Affinity DataIC50: <1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM334083(5-{[(3S)-1- (cyclopropylcarbonyl)pyrrolidin- 3-yl]...)
Affinity DataIC50: <1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM334119(6-{[(3S)-1- (cyclopropylcarbonyl)pyrrolidin- 3-yl]...)
Affinity DataIC50: <1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM334081(6-{[(3S)-1- (cyclopropylcarbonyl)pyrrolidin- 3-yl]...)
Affinity DataIC50: <1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50522155(CHEMBL4452905)
Affinity DataIC50:  1nMAssay Description:Inhibition of PI3KD (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM334079(6-{[(3S)-1- (cyclopropylcarbonyl)pyrrolidin- 3-yl]...)
Affinity DataIC50: <1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM334043(6-{[(3S)-1- (cyclopropylcarbonyl)pyrrolidin- 3-yl]...)
Affinity DataIC50:  1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM334016(9-ethyl-6-({(3S)-1-[([(1R,2S) or (1R,2R) or (1S,2R...)
Affinity DataIC50: <1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM334032(9-ethyl-6-{[(3S)-1-{[(1S,2S)- or (1R,2R)-2- (fluor...)
Affinity DataIC50:  1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM334099(N-[5-(6-{[(3S)-1- (cyclopropylcarbonyl)pyrrolidin-...)
Affinity DataIC50: <1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM334114(6-({(3S)-1-[(3,3- difluorocyclobutyl)carbonyl]pyr-...)
Affinity DataIC50: <1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM334108(6-{[(3S)-1- (cyclopropylcarbonyl)pyrrolidin- 3-yl]...)
Affinity DataIC50: <1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM334110(6-({(3S)-1-[(3,3- difluorocyclobutyl)carbonyl]pyr-...)
Affinity DataIC50: <1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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