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Found 96 with Last Name = 'gassen' and Initial = 'm'
LigandPNGBDBM16117(3-{[2,3,5,6-tetrafluoro-4-(2-methoxyphenyl)phenyl]...)
Affinity DataIC50:  1nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Carlsson Research

Curated by ChEMBL
LigandPNGBDBM50171241(2-Phenyl-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-in...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16115(3-{[4-(3-ethoxyphenyl)-2,6-difluorophenyl]carbamoy...)
Affinity DataIC50:  3nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50173155(4-(2,3,5,6-Tetrafluoro-3'-trifluoromethoxy-bipheny...)
Affinity DataIC50:  4nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM15344(2-({2,3,5,6-tetrafluoro-4-[3-(trifluoromethoxy)phe...)
Affinity DataIC50:  7nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Carlsson Research

Curated by ChEMBL
LigandPNGBDBM50171235(5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4-...)
Affinity DataIC50:  7.40nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 6 receptor in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Carlsson Research

Curated by ChEMBL
LigandPNGBDBM50171235(5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4-...)
Affinity DataIC50:  7.40nMAssay Description:Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM15339(6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-qui...)
Affinity DataIC50:  8nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
LigandPNGBDBM16112(2-{[2,3,5,6-tetrafluoro-4-(2-methoxyphenyl)phenyl]...)
Affinity DataIC50:  8nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
4Sc

Curated by ChEMBL
LigandPNGBDBM14712((2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)pheny...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity against rat dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
LigandPNGBDBM16116(3-{[4-(2-ethoxyphenyl)-2,6-difluorophenyl]carbamoy...)
Affinity DataIC50:  9nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16121(4-({2,6-difluoro-4-[3-(trifluoromethoxy)phenyl]phe...)
Affinity DataIC50:  10nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16120(4-{[4-(2-ethoxyphenyl)-2,6-difluorophenyl]carbamoy...)
Affinity DataIC50:  10nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Carlsson Research

Curated by ChEMBL
LigandPNGBDBM50171237(5-Chloro-2-methyl-3-(1-methyl-1,2,3,6-tetrahydro-p...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50173152(2-(3,5-Difluoro-3'-methoxy-biphenyl-4-ylcarbamoyl)...)
Affinity DataIC50:  11nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50173145(2-[3-Chloro-4-(2-chloro-6-fluoro-benzyloxy)-phenyl...)
Affinity DataIC50:  11nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16118(3-{[3-chloro-4-(2-methoxyphenyl)phenyl]carbamoyl}t...)
Affinity DataIC50:  12nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50173151(4-(3,5-Difluoro-3'-trifluoromethoxy-biphenyl-4-ylc...)
Affinity DataIC50:  15nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16125(4-{[4-(3-ethoxyphenyl)-2,6-difluorophenyl]carbamoy...)
Affinity DataIC50:  16nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Carlsson Research

Curated by ChEMBL
LigandPNGBDBM50171239(5-Chloro-2-ethyl-3-(1,2,3,6-tetrahydro-pyridin-4-y...)
Affinity DataIC50:  30nMAssay Description:Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Carlsson Research

Curated by ChEMBL
LigandPNGBDBM50171242(5-Chloro-3-(1-ethyl-1,2,3,6-tetrahydro-pyridin-4-y...)
Affinity DataIC50:  30nMAssay Description:Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM15343(2-({2,6-difluoro-4-[3-(trifluoromethoxy)phenyl]phe...)
Affinity DataIC50:  33nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Carlsson Research

Curated by ChEMBL
LigandPNGBDBM50171235(5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4-...)
Affinity DataIC50:  34nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 3 receptor expressed in NG 108 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Carlsson Research

Curated by ChEMBL
LigandPNGBDBM50171234(CHEMBL365751 | [2-(5-Chloro-2-methyl-1H-indol-3-yl...)
Affinity DataIC50:  40nMAssay Description:Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Carlsson Research

Curated by ChEMBL
LigandPNGBDBM50171243(5-Chloro-2-methyl-3-(8-methyl-8-aza-bicyclo[3.2.1]...)
Affinity DataIC50:  40nMAssay Description:Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Carlsson Research

Curated by ChEMBL
LigandPNGBDBM50171245(5-Chloro-2-propyl-3-(1,2,3,6-tetrahydro-pyridin-4-...)
Affinity DataIC50:  40nMAssay Description:Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50173144(4-[3-Chloro-4-(2-chloro-6-fluoro-benzyloxy)-phenyl...)
Affinity DataIC50:  41nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
Carlsson Research

Curated by ChEMBL
LigandPNGBDBM34142(2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...)
Affinity DataIC50:  44nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 4 receptor in guinea pigMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16114(3-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}t...)
Affinity DataIC50:  44nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Carlsson Research

Curated by ChEMBL
LigandPNGBDBM50171240(3-(1-Butyl-1,2,3,6-tetrahydro-pyridin-4-yl)-5-chlo...)
Affinity DataIC50:  50nMAssay Description:Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50173159(4-(2,3,5,6-Tetrafluoro-3'-trifluoromethoxy-bipheny...)
Affinity DataIC50:  58nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Carlsson Research

Curated by ChEMBL
LigandPNGBDBM50171246(5-Chloro-2-methyl-3-(1-propyl-1,2,3,6-tetrahydro-p...)
Affinity DataIC50:  60nMAssay Description:Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Carlsson Research

Curated by ChEMBL
LigandPNGBDBM50171244(5-Chloro-2-ethyl-3-(1-ethyl-1,2,3,6-tetrahydro-pyr...)
Affinity DataIC50:  70nMAssay Description:Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
4Sc

Curated by ChEMBL
LigandPNGBDBM15344(2-({2,3,5,6-tetrafluoro-4-[3-(trifluoromethoxy)phe...)
Affinity DataIC50:  78nMAssay Description:Inhibitory activity against rat dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Carlsson Research

Curated by ChEMBL
LigandPNGBDBM81498(5-Methoxy-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-i...)
Affinity DataIC50:  79nMAssay Description:Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Carlsson Research

Curated by ChEMBL
LigandPNGBDBM50171236(5-Methoxy-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4...)
Affinity DataIC50:  80nMAssay Description:Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Carlsson Research

Curated by ChEMBL
LigandPNGBDBM50171236(5-Methoxy-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 6 receptor in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Carlsson Research

Curated by ChEMBL
LigandPNGBDBM34142(2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...)
Affinity DataIC50:  85nMAssay Description:Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor stably expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Carlsson Research

Curated by ChEMBL
LigandPNGBDBM34142(2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...)
Affinity DataIC50:  85nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 6 receptor in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Carlsson Research

Curated by ChEMBL
LigandPNGBDBM50171233(2-Ethyl-5-methoxy-3-(1,2,3,6-tetrahydro-pyridin-4-...)
Affinity DataIC50:  90nMAssay Description:Displacement of [3H]-LSD binding to cloned h5-HT6 receptors stably expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Carlsson Research

Curated by ChEMBL
LigandPNGBDBM50171238(5-Chloro-2-isopropyl-3-(1,2,3,6-tetrahydro-pyridin...)
Affinity DataIC50:  100nMAssay Description:Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50173148(4-[3,5-Dibromo-4-(2-chloro-6-fluoro-benzyloxy)-phe...)
Affinity DataIC50:  105nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50173158(2-[3,5-Dibromo-4-(2-chloro-6-fluoro-benzyloxy)-phe...)
Affinity DataIC50:  110nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Carlsson Research

Curated by ChEMBL
LigandPNGBDBM50171235(5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4-...)
Affinity DataIC50:  110nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1B receptor in calfMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50173161(2-(4-Benzyloxy-3,5-dibromo-phenylcarbamoyl)-cyclop...)
Affinity DataIC50:  127nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50173149(4-(3-Fluoro-3'-methoxy-biphenyl-4-ylcarbamoyl)-2,5...)
Affinity DataIC50:  131nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16111(2-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}c...)
Affinity DataIC50:  134nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM16111(2-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}c...)
Affinity DataIC50:  134nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14712((2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)pheny...)
Affinity DataIC50:  156nMAssay Description:Inhibitory activity against mouse dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50173146(4-(4-Benzyloxy-3,5-dibromo-phenylcarbamoyl)-2,5-di...)
Affinity DataIC50:  173nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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