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Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50173146
Substrate
n/a
Meas. Tech.
ChEMBL_321456 (CHEMBL879486)
IC50
173±n/a nM
Citation
 Leban, J; Kralik, M; Mies, J; Gassen, M; Tentschert, K; Baumgartner, R SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors. Bioorg Med Chem Lett 15:4854-7 (2005) [PubMed]  Article 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM50173146
Synonyms:
4-(4-Benzyloxy-3,5-dibromo-phenylcarbamoyl)-2,5-dihydro-thiophene-3-carboxylic acid | CHEMBL195246
Type:
Small organic molecule
Emp. Form.:
C19H15Br2NO4S
Mol. Mass.:
513.2
SMILES:
OC(=O)C1=C(CSC1)C(=O)Nc1cc(Br)c(OCc2ccccc2)c(Br)c1 |t:3|
Structure:
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