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Found 57 with Last Name = 'kralik' and Initial = 'm'
LigandPNGBDBM16117(3-{[2,3,5,6-tetrafluoro-4-(2-methoxyphenyl)phenyl]...)
Affinity DataIC50:  1nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM15341(3-({2,6-difluoro-4-[3-(trifluoromethoxy)phenyl]phe...)
Affinity DataIC50:  2nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
LigandPNGBDBM16115(3-{[4-(3-ethoxyphenyl)-2,6-difluorophenyl]carbamoy...)
Affinity DataIC50:  3nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50173155(4-(2,3,5,6-Tetrafluoro-3'-trifluoromethoxy-bipheny...)
Affinity DataIC50:  4nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM15344(2-({2,3,5,6-tetrafluoro-4-[3-(trifluoromethoxy)phe...)
Affinity DataIC50:  7nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM15344(2-({2,3,5,6-tetrafluoro-4-[3-(trifluoromethoxy)phe...)
Affinity DataIC50:  7nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM15339(6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-qui...)
Affinity DataIC50:  7nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
LigandPNGBDBM15339(6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-qui...)
Affinity DataIC50:  8nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
LigandPNGBDBM16112(2-{[2,3,5,6-tetrafluoro-4-(2-methoxyphenyl)phenyl]...)
Affinity DataIC50:  8nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16116(3-{[4-(2-ethoxyphenyl)-2,6-difluorophenyl]carbamoy...)
Affinity DataIC50:  9nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
4Sc

Curated by ChEMBL
LigandPNGBDBM14712((2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)pheny...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity against rat dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
LigandPNGBDBM16120(4-{[4-(2-ethoxyphenyl)-2,6-difluorophenyl]carbamoy...)
Affinity DataIC50:  10nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16121(4-({2,6-difluoro-4-[3-(trifluoromethoxy)phenyl]phe...)
Affinity DataIC50:  10nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50173152(2-(3,5-Difluoro-3'-methoxy-biphenyl-4-ylcarbamoyl)...)
Affinity DataIC50:  11nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50173145(2-[3-Chloro-4-(2-chloro-6-fluoro-benzyloxy)-phenyl...)
Affinity DataIC50:  11nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16118(3-{[3-chloro-4-(2-methoxyphenyl)phenyl]carbamoyl}t...)
Affinity DataIC50:  12nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50173151(4-(3,5-Difluoro-3'-trifluoromethoxy-biphenyl-4-ylc...)
Affinity DataIC50:  15nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16125(4-{[4-(3-ethoxyphenyl)-2,6-difluorophenyl]carbamoy...)
Affinity DataIC50:  16nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM15343(2-({2,6-difluoro-4-[3-(trifluoromethoxy)phenyl]phe...)
Affinity DataIC50:  33nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
LigandPNGBDBM15343(2-({2,6-difluoro-4-[3-(trifluoromethoxy)phenyl]phe...)
Affinity DataIC50:  33nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
LigandPNGBDBM50173144(4-[3-Chloro-4-(2-chloro-6-fluoro-benzyloxy)-phenyl...)
Affinity DataIC50:  41nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16114(3-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}t...)
Affinity DataIC50:  44nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
LigandPNGBDBM16114(3-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}t...)
Affinity DataIC50:  44nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
LigandPNGBDBM50173159(4-(2,3,5,6-Tetrafluoro-3'-trifluoromethoxy-bipheny...)
Affinity DataIC50:  58nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
4Sc

Curated by ChEMBL
LigandPNGBDBM15344(2-({2,3,5,6-tetrafluoro-4-[3-(trifluoromethoxy)phe...)
Affinity DataIC50:  78nMAssay Description:Inhibitory activity against rat dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50173148(4-[3,5-Dibromo-4-(2-chloro-6-fluoro-benzyloxy)-phe...)
Affinity DataIC50:  105nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50173158(2-[3,5-Dibromo-4-(2-chloro-6-fluoro-benzyloxy)-phe...)
Affinity DataIC50:  110nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50173161(2-(4-Benzyloxy-3,5-dibromo-phenylcarbamoyl)-cyclop...)
Affinity DataIC50:  127nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50173149(4-(3-Fluoro-3'-methoxy-biphenyl-4-ylcarbamoyl)-2,5...)
Affinity DataIC50:  131nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16111(2-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}c...)
Affinity DataIC50:  134nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16111(2-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}c...)
Affinity DataIC50:  134nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14712((2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)pheny...)
Affinity DataIC50:  156nMAssay Description:Inhibitory activity against mouse dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
LigandPNGBDBM50173146(4-(4-Benzyloxy-3,5-dibromo-phenylcarbamoyl)-2,5-di...)
Affinity DataIC50:  173nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50173160(4-(3,5-Difluoro-3'-trifluoromethoxy-biphenyl-4-ylc...)
Affinity DataIC50:  205nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM1542(2-({2-fluoro-4-[3-(trifluoromethoxy)phenyl]phenyl}...)
Affinity DataIC50:  280nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
LigandPNGBDBM16113(3-[(4-phenylphenyl)carbamoyl]thiophene-2-carboxyli...)
Affinity DataIC50:  303nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM16126(4-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}f...)
Affinity DataIC50:  340nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50173156(4-(3-Fluoro-3'-methoxy-biphenyl-4-ylcarbamoyl)-2,5...)
Affinity DataIC50:  360nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16109(2-[(4-phenylphenyl)carbamoyl]cyclopent-1-ene-1-car...)
Affinity DataIC50:  410nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16109(2-[(4-phenylphenyl)carbamoyl]cyclopent-1-ene-1-car...)
Affinity DataIC50:  410nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14712((2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)pheny...)
Affinity DataIC50:  420nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
LigandPNGBDBM15344(2-({2,3,5,6-tetrafluoro-4-[3-(trifluoromethoxy)phe...)
Affinity DataIC50:  422nMAssay Description:Inhibitory activity against mouse dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
4Sc

Curated by ChEMBL
LigandPNGBDBM15343(2-({2,6-difluoro-4-[3-(trifluoromethoxy)phenyl]phe...)
Affinity DataIC50:  504nMAssay Description:Inhibitory activity against rat dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
LigandPNGBDBM50173157(4-(Biphenyl-4-ylcarbamoyl)-2,5-dihydro-thiophene-3...)
Affinity DataIC50:  667nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50173153(2-(3-Fluoro-3'-methoxy-biphenyl-4-ylcarbamoyl)-5-h...)
Affinity DataIC50:  680nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16123(3-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}t...)
Affinity DataIC50: >1.00E+3nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16119(4-[(4-phenylphenyl)carbamoyl]thiophene-3-carboxyli...)
Affinity DataIC50:  1.00E+3nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM16122(3-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}t...)
Affinity DataIC50: >1.00E+3nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16124(4-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}t...)
Affinity DataIC50: >1.00E+3nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
4Sc

Curated by ChEMBL
LigandPNGBDBM50173144(4-[3-Chloro-4-(2-chloro-6-fluoro-benzyloxy)-phenyl...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibitory activity against rat dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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