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Found 32 with Last Name = 'goldstein' and Initial = 'sw'
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50012764((+/-)-6'-chloro-2'-methyl-(2'R,4'S)-spiro[1H,2H-im...)
Affinity DataIC50:  25nMAssay Description:In vitro inhibitory activity against Aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50012764((+/-)-6'-chloro-2'-methyl-(2'R,4'S)-spiro[1H,2H-im...)
Affinity DataIC50:  25nMAssay Description:In vitro inhibitory activity against Aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50012762((+)6'-chloro-2'-methyl-2,5-dioxo-(2'R,4'S)-spiro[1...)
Affinity DataIC50:  130nMAssay Description:In vitro inhibitory activity against Aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50012762((+)6'-chloro-2'-methyl-2,5-dioxo-(2'R,4'S)-spiro[1...)
Affinity DataIC50:  130nMAssay Description:In vitro inhibitory activity against Aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)
Affinity DataIC50:  170nMAssay Description:In vitro inhibitory activity against Aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50012761((+/-)-6'-bromo-2'-methyl-(2'R,4'S)-spiro[1H,2H-imi...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibitory activity against Aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50012767((+/-)-6'-chloro-2'-methyl-(2'S,4'S)-spiro[1H,2H-im...)
Affinity DataIC50:  890nMAssay Description:In vitro inhibitory activity against Aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397731(CHEMBL2181984)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of recombinant BACE1 using NH-SEVNLAAEF-COOH as substrate after 30 mins by NMR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50012760((+/-)-6'-fluoro-2'-methyl-(2'R,4'S)-spiro[1H,2H-im...)
Affinity DataIC50:  1.13E+3nMAssay Description:In vitro inhibitory activity against Aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397733(CHEMBL2181982)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant BACE1 using NH-SEVNLAAEF-COOH as substrate after 30 mins by NMR analysisMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50012763((-)-6'-chloro-2'-methyl-(2'S,4'R)-spiro[1H,2H-imid...)
Affinity DataIC50:  3.09E+3nMAssay Description:In vitro inhibitory activity against Aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397731(CHEMBL2181984)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human recombinant BACE1 using RGLTTRPGSGLTNIKTEEISEVNLDAEFRHDSGA as substrate after 1 hr by TMB-ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50280717(CHEMBL557974 | CP-99711 | N-[6,7-Dichloro-3-((E)-s...)
Affinity DataIC50:  4.00E+3nMAssay Description:Tested against glucagon receptor for its ability to displace radiolabelled ([125I]-glucagon) in male Dawley rat liverMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397732(CHEMBL2181983)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of recombinant BACE1 using NH-SEVNLAAEF-COOH as substrate after 30 mins by NMR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397733(CHEMBL2181982)
Affinity DataIC50:  6.26E+3nMAssay Description:Inhibition of human recombinant BACE1 using RGLTTRPGSGLTNIKTEEISEVNLDAEFRHDSGA as substrate after 1 hr by TMB-ELISAMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50012765((+/-)-6'-chloro-(4'S)-spiro[1H,2H-imidazole-4,4'-(...)
Affinity DataIC50:  6.45E+3nMAssay Description:In vitro inhibitory activity against Aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397735(CHEMBL2181980)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of recombinant BACE1 using NH-SEVNLAAEF-COOH as substrate after 30 mins by NMR analysisMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50012766((+/-)-2'-methyl-(2'R,4'S)-spiro[1H,2H-imidazole-4,...)
Affinity DataIC50:  7.22E+3nMAssay Description:In vitro inhibitory activity against Aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397730(CHEMBL2181985)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of recombinant BACE1 using NH-SEVNLAAEF-COOH as substrate after 30 mins by NMR analysisMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397735(CHEMBL2181980)
Affinity DataIC50:  1.22E+4nMAssay Description:Inhibition of human recombinant BACE1 using RGLTTRPGSGLTNIKTEEISEVNLDAEFRHDSGA as substrate after 1 hr by TMB-ELISAMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397737(CHEMBL2181978)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of recombinant BACE1 using NH-SEVNLAAEF-COOH as substrate after 30 mins by NMR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397732(CHEMBL2181983)
Affinity DataIC50:  2.26E+4nMAssay Description:Inhibition of human recombinant BACE1 using RGLTTRPGSGLTNIKTEEISEVNLDAEFRHDSGA as substrate after 1 hr by TMB-ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397730(CHEMBL2181985)
Affinity DataIC50:  2.54E+4nMAssay Description:Inhibition of human recombinant BACE1 using RGLTTRPGSGLTNIKTEEISEVNLDAEFRHDSGA as substrate after 1 hr by TMB-ELISAMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397734(CHEMBL2181981)
Affinity DataIC50:  2.95E+4nMAssay Description:Inhibition of human recombinant BACE1 using RGLTTRPGSGLTNIKTEEISEVNLDAEFRHDSGA as substrate after 1 hr by TMB-ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397738(CHEMBL2181998)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of recombinant BACE1 using NH-SEVNLAAEF-COOH as substrate after 30 mins by NMR analysisMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397736(CHEMBL2181979)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of recombinant BACE1 using NH-SEVNLAAEF-COOH as substrate after 30 mins by NMR analysisMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397737(CHEMBL2181978)
Affinity DataIC50:  8.37E+4nMAssay Description:Inhibition of human recombinant BACE1 using RGLTTRPGSGLTNIKTEEISEVNLDAEFRHDSGA as substrate after 1 hr by TMB-ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397736(CHEMBL2181979)
Affinity DataIC50:  8.57E+4nMAssay Description:Inhibition of human recombinant BACE1 using RGLTTRPGSGLTNIKTEEISEVNLDAEFRHDSGA as substrate after 1 hr by TMB-ELISAMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397738(CHEMBL2181998)
Affinity DataIC50:  1.14E+5nMAssay Description:Inhibition of human recombinant BACE1 using RGLTTRPGSGLTNIKTEEISEVNLDAEFRHDSGA as substrate after 1 hr by TMB-ELISAMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397739(CHEMBL2181997)
Affinity DataIC50:  2.42E+5nMAssay Description:Inhibition of recombinant BACE1 using NH-SEVNLAAEF-COOH as substrate after 30 mins by NMR analysisMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397740(CHEMBL2181988)
Affinity DataIC50:  1.10E+6nMAssay Description:Inhibition of recombinant BACE1 using NH-SEVNLAAEF-COOH as substrate after 30 mins by NMR analysisMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397740(CHEMBL2181988)
Affinity DataKd:  1.40E+6nMAssay Description:Inhibition of recombinant BACE1 binding to biotinylated stat-val peptide after 6 mins by octet assayMore data for this Ligand-Target Pair