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Found 624 with Last Name = 'green' and Initial = 'n'
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50558084(CHEMBL4799933)
Affinity DataKi:  740nMAssay Description:Uncompetitive inhibition of recombinant human full length Avi-tagged p97 (1 to 806 residues) expressed in Escherichia coli Rosetta 2(DE3) using 20 uM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50558084(CHEMBL4799933)
Affinity DataKi:  3.50E+3nMAssay Description:Competitive inhibition of recombinant human full length Avi-tagged p97 (1 to 806 residues) expressed in Escherichia coli Rosetta 2(DE3) using 20 uM A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209479((beta1S)-3-bromo-5-chloro-b-[[[[3-[(5-fluoro-1,4,5...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209482((3S)-3-(5-chloro-2-hydroxy-3-methylphenyl)-3-(2-(3...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209471((3S)-3-(5-bromo-3-chloro-2-hydroxyphenyl)-3-(2-(3-...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209446((3S)-3-(3,5-dichloro-2-hydroxyphenyl)-3-(2-(3-(5-h...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209459((3R)-3-(2-(3-amino-5-(5-hydroxy-1,4,5,6-tetrahydro...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209441((3S)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-(2-(3-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209461((3S)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-(2-(3-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209450((beta1R)-3-bromo-5-chloro-b-[[[[3-[(5-fluoro-1,4,5...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209456((3S)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-(2-(3-...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209475((3R)-3-(3,5-dichloro-2-hydroxyphenyl)-3-(2-(3-(5-h...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209428((3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-(2-(3-...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209463((beta1S)-3,5-dichloro-b-[[[[3-[(5-hydroxy-1,4,5,6-...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209486((S)-3-(3,5-dichloro-2-hydroxyphenyl)-3-(2-(3-hydro...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209483((beta1R)-3-bromo-5-chloro-b-[[[[3-[(5-fluoro-1,4,5...)
Affinity DataIC50:  1nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209477((beta1R)-3-bromo-5-chloro-b-[[[[3-[(5-fluoro-1,4,5...)
Affinity DataIC50:  1nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209439((3R)-3-(5-chloro-2-hydroxy-3-iodophenyl)-3-(2-(3-(...)
Affinity DataIC50:  1nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209448((3R)-3-(3,5-dichloro-2-hydroxyphenyl)-3-(2-(3-(5-f...)
Affinity DataIC50:  1nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209481((3R)-3-(5-chloro-2-hydroxy-3-iodophenyl)-3-(2-(3-(...)
Affinity DataIC50:  1nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209489((3R)-3-(3,5-dichloro-2-hydroxyphenyl)-3-(2-(3-(5-f...)
Affinity DataIC50:  1nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209425((3R)-3-(5-bromo-3-chloro-2-hydroxyphenyl)-3-(2-(3-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209431((3R)-3-(3,5-dichloro-2-hydroxyphenyl)-3-(2-(3-(5-f...)
Affinity DataIC50:  1nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209488((3S)-3-(2-hydroxy-3,5-dimethylphenyl)-3-(2-(3-hydr...)
Affinity DataIC50:  1nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209460((3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-(2-(3-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29923(US11066414, Comparative Example 1 | substituted 6-...)
Affinity DataIC50:  1.60nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209487((3S)-3-(5-chloro-2-hydroxy-3-iodophenyl)-3-(2-(3-(...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209438((3R)-3-(3,5-dibromo-2-hydroxyphenyl)-3-(2-(3-(5-hy...)
Affinity DataIC50:  2nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209469((S)-3-bromo-5-chloro-2-hydroxy-b-[[2-[[[3-hydroxy-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21922(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(2H...)
Affinity DataIC50:  2nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209452((S)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-(2-(3-(...)
Affinity DataIC50:  2nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29910(substituted 6-aminoquinoline-3-carbonitrile, 21)
Affinity DataIC50:  2nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209453((3R)-3-(5-bromo-3-chloro-2-hydroxyphenyl)-3-(2-(3-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50173838(4-(4-benzylphenylamino)-6-(2-morpholinoethylamino)...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29922(substituted 6-aminoquinoline-3-carbonitrile, 33)
Affinity DataIC50:  2.20nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209457((3S)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-(2-(3-...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209449((3S)-3-(5-bromo-3-chloro-2-hydroxyphenyl)-3-(2-(3-...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50194988(4-(3-chloro-4-fluorophenylamino)-6-((1,5-dimethyl-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Tpl2 kinase by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209468((3R)-3-(3,5-dibromo-2-hydroxyphenyl)-3-(2-(3-(5-fl...)
Affinity DataIC50:  3nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209474((3R)-3-(5-bromo-3-chloro-2-hydroxyphenyl)-3-(2-(3-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209458((beta1R)-3,5-dichloro-b-[[[[3-[(5-hydroxy-1,4,5,6-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209424((3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-(2-(3-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209445((3R)-3-(2-(3-amino-5-(5-fluoro-1,4,5,6-tetrahydrop...)
Affinity DataIC50:  3nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209466((3R)-3-(5-chloro-2-hydroxy-3-iodophenyl)-3-(2-(3-h...)
Affinity DataIC50:  3nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209462((R)-3-(3,5-dichloro-2-hydroxyphenyl)-3-(2-(3-hydro...)
Affinity DataIC50:  3nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209436((3R)-3-(5-chloro-2-hydroxy-3-iodophenyl)-3-(2-(3-(...)
Affinity DataIC50:  3nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50194998(4-(3-chloro-4-fluorophenylamino)-6-((5-methyl-1H-i...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Tpl2 kinase by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29912(substituted 6-aminoquinoline-3-carbonitrile, 23)
Affinity DataIC50:  3nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209472((R)-3-(3,5-dibromo-2-hydroxyphenyl)-3-(2-(3-(1,4,5...)
Affinity DataIC50:  4nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209473((R)-3-(3,5-dichloro-2-hydroxyphenyl)-3-(2-(3-(1,4,...)
Affinity DataIC50:  4nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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