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Found 1568 with Last Name = 'guba' and Initial = 'w'
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM603932((+)-trans-Ethyl 2-ethyl-2-{[6-({-2-[(fluoromethoxy...)
Affinity DataKi:  0.200nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM603936((+)-trans-2-Fluoroethyl 2-ethyl-2-{[6-{[-2-(hydrox...)
Affinity DataKi:  0.300nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM603935((−)-trans-Fluoromethyl 2-ethyl-2-{[6-{[-2-(h...)
Affinity DataKi:  0.400nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM603926(Ethyl 2-ethyl-2-{[6-{[(1S,2S)-2-(fluoromethyl)cycl...)
Affinity DataKi:  0.5nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50048466(2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity against human Adenosine A2a receptor (hA2a)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM603938(3-Fluoropropyl 2-ethyl-2-{[6-{[(1S,2S)-2-(hydroxym...)
Affinity DataKi:  0.700nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM603927(Ethyl 2-ethyl-2-{[6-{[(1R,2S)-2-(fluoromethyl)cycl...)
Affinity DataKi:  0.700nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM603938(3-Fluoropropyl 2-ethyl-2-{[6-{[(1S,2S)-2-(hydroxym...)
Affinity DataKi:  0.800nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419188(5-[Difluoro(phenyl)methyl]-7-(1,2,5-triazaspiro[2....)
Affinity DataKi:  0.800nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM21190(4-(2-{[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity against human Adenosine A2a receptor (hA2a)More data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM86998((2,2-bis(2,4-difluorophenyl)-6-fluorobenzo[d][1,3]...)
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419309(2-[[5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)tr...)
Affinity DataKi:  1nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM603952(3-Fluoropropyl 2-ethyl-2-{[5-(3-fluoroazetidin-1-y...)
Affinity DataKi:  1.70nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM603947(4-Fluorobutyl 2-ethyl-2-[[6-[[(1S,2S)-2-(hydroxyme...)
Affinity DataKi:  1.80nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM603924(Ethyl 2-ethyl-2-{[6-({(1S,2S)-2-[(fluoromethoxy)me...)
Affinity DataKi:  1.80nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50147656(CHEMBL113967 | [5-Amino-2-(5-bromo-furan-2-yl)-[1,...)
Affinity DataKi:  2nMAssay Description:Binding affinity against human Adenosine A2a receptor (hA2a)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50147665(CHEMBL112773 | [5-Amino-2-(5-bromo-furan-2-yl)-[1,...)
Affinity DataKi:  2nMAssay Description:Binding affinity against human Adenosine A2a receptor (hA2a)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM87007((2-(2,4-dichlorophenyl)-6-fluoro-2-(4-methoxypheny...)
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM603930(Ethyl 2-{[6-(cyclopropylmethoxy)-4-fluoro-5-(3-met...)
Affinity DataKi:  2.5nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50147647(5-Amino-2-(5-bromo-furan-2-yl)-[1,2,4]triazolo[1,5...)
Affinity DataKi:  3nMAssay Description:Binding affinity against human Adenosine A2a receptor (hA2a)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50147651(5-Amino-2-(5-bromo-furan-2-yl)-[1,2,4]triazolo[1,5...)
Affinity DataKi:  3nMAssay Description:Binding affinity against human Adenosine A2a receptor (hA2a)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50147655(CHEMBL323945 | [5-Amino-2-(5-bromo-furan-2-yl)-[1,...)
Affinity DataKi:  3nMAssay Description:Binding affinity against human Adenosine A2a receptor (hA2a)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM86989(1-(2,2-bis(2,4-difluorophenyl)-6-fluorobenzo[d][1,...)
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM86984((R)-[2-(2,4-dichloro-phenyl)-6-fluoro-2-(4-fluoro-...)
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50311334(2-(1-(4-chloro-3,5-diethoxybenzyl)piperidin-4-ylam...)
Affinity DataKi:  3nMAssay Description:Displacement of SST14 from human recombinant SST5 receptor expressed in CHO cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419190(5-tert-Butyl-3-[(2-chlorophenyl)methyl]-7-(1,2,5-t...)
Affinity DataKi:  3.30nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM86984((R)-[2-(2,4-dichloro-phenyl)-6-fluoro-2-(4-fluoro-...)
Affinity DataKi:  3.30nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM603925(Ethyl 2-ethyl-2-{[6-({(1S,2S)-2-[(2-fluoroethoxy)m...)
Affinity DataKi:  3.70nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50147669(CHEMBL110074 | [5-Amino-2-(5-bromo-furan-2-yl)-[1,...)
Affinity DataKi:  4nMAssay Description:Binding affinity against human Adenosine A2a receptor (hA2a)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50147672(5-Amino-2-(5-bromo-furan-2-yl)-[1,2,4]triazolo[1,5...)
Affinity DataKi:  4nMAssay Description:Binding affinity against human Adenosine A2a receptor (hA2a)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM86995((2-(2,4-dichlorophenyl)-6-fluoro-2-(2-fluorophenyl...)
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM87003((2-(2,4-dichlorophenyl)-6-fluoro-2-(4-fluorophenyl...)
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM86984((R)-[2-(2,4-dichloro-phenyl)-6-fluoro-2-(4-fluoro-...)
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419260(5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-({2...)
Affinity DataKi:  4.20nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM603928(Ethyl 2-ethyl-2-{[6-({(1R,2S)-2-[(fluoromethoxy)me...)
Affinity DataKi:  4.60nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50147644(5-Amino-2-(5-bromo-furan-2-yl)-[1,2,4]triazolo[1,5...)
Affinity DataKi:  5nMAssay Description:Binding affinity against human Adenosine A2a receptor (hA2a)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419306(3-[2-[2-[[5-tert-Butyl-7-(3,3-difluoropyrrolidin-1...)
Affinity DataKi:  5nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
University Of Hamburg

Curated by ChEMBL
LigandPNGBDBM50085406((2R,3R)-3-[(Biphenyl-4-carbonyl)-amino]-2-(3-carba...)
Affinity DataKi:  5.30nMAssay Description:Inhibition of factor 10a (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419261(5-tert-Butyl-3-[(2-ethynylphenyl)methyl]-7-(1,2,5-...)
Affinity DataKi:  5.60nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50147638(CHEMBL324077 | [5-Amino-2-(5-bromo-furan-2-yl)-[1,...)
Affinity DataKi:  6nMAssay Description:Binding affinity against human Adenosine A2a receptor (hA2a)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50147670(5-Amino-2-(5-bromo-furan-2-yl)-[1,2,4]triazolo[1,5...)
Affinity DataKi:  6nMAssay Description:Binding affinity against human Adenosine A2a receptor (hA2a)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419300(2-[2-[2-[[5-tert-Butyl-7-(3,3-difluoropyrrolidin-1...)
Affinity DataKi:  6nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM419278(2-{[5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-3...)
Affinity DataKi:  6nMAssay Description:he affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM21278(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...)
In DepthDetails ArticlePubMedDrugBank

TargetCannabinoid receptor 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM86997((6-fluoro-2,2-bis(4-fluorophenyl)benzo[d][1,3]diox...)
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM86992((2,2-bis(2,4-difluorophenyl)-6-fluorobenzo[d][1,3]...)
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50147648(1-[5-Amino-2-(5-bromo-furan-2-yl)-[1,2,4]triazolo[...)
Affinity DataKi:  8nMAssay Description:Binding affinity against human Adenosine A2a receptor (hA2a)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50311333(2-(1-(3,5-diethoxy-4-fluorobenzyl)piperidin-4-ylam...)
Affinity DataKi:  8nMAssay Description:Displacement of SST14 from human recombinant SST5 receptor expressed in CHO cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM29094((+/-)-SLV319 | (S)-3-(4-chlorophenyl)-N-(4-chlorop...)
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM603933((−)-trans-Ethyl 2-ethyl-2-{[6-({-2-[(fluorom...)
Affinity DataKi:  8.20nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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