Affinity DataKi: 0.0380nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesiense rhodesain expressed in Pichia pastoris using Cbz-Phe-Arg-AMC as substrate after 30 min by fl...More data for this Ligand-Target Pair
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli (strain K12))
Albert Einstein College of Medicine
Albert Einstein College of Medicine
Affinity DataKi: 0.0700nM ΔG°: -58.0kJ/molepH: 7.5 T: 2°CAssay Description:Purified MTAN activity in MTAN enzyme inhibition assayMore data for this Ligand-Target Pair
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli (strain K12))
Albert Einstein College of Medicine
Albert Einstein College of Medicine
Affinity DataKi: 0.0730nM ΔG°: -57.9kJ/molepH: 7.5 T: 2°CAssay Description:Purified MTAN activity in MTAN enzyme inhibition assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.0740nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesiense rhodesain expressed in Pichia pastoris using Cbz-Phe-Arg-AMC as substrate after 30 min by fl...More data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 0.0900nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli (strain K12))
Albert Einstein College of Medicine
Albert Einstein College of Medicine
Affinity DataKi: 0.208nM ΔG°: -55.3kJ/molepH: 7.5 T: 2°CAssay Description:Purified MTAN activity in MTAN enzyme inhibition assayMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(RAT)
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 0.340nMAssay Description:Tested for its binding affinity towards sigma-1 site in rat brain, using [3H](+)-3-PPP as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Inhibition of human cathepsin L using Cbz-Phe-Arg-AMC as substrate after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesiense rhodesain expressed in Pichia pastoris using Cbz-Phe-Arg-AMC as substrate after 30 min by fl...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
University Of Chile
Curated by ChEMBL
University Of Chile
Curated by ChEMBL
Affinity DataKi: 0.600nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR overexpressed in human SHEP cells after 75 mins by liquid scintillation spectrometric analy...More data for this Ligand-Target Pair
Affinity DataKi: 0.610nMAssay Description:Inhibition of human cathepsin L using Cbz-Phe-Arg-AMC as substrate after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Centro De InvestigacióN Grupo Ferrer
Curated by ChEMBL
Centro De InvestigacióN Grupo Ferrer
Curated by ChEMBL
Affinity DataKi: 0.700nMAssay Description:Binding affinity measured at the 5-hydroxytryptamine 2A receptor by the inhibition of [3H]-ketanserin binding to rat cortex using unlabeled mianserin...More data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 0.800nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 0.800nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesiense rhodesain expressed in Pichia pastoris using Cbz-Phe-Arg-AMC as substrate after 30 min by fl...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Binding affinity towards muscarinic m2 receptorMore data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
University Of Chile
Curated by ChEMBL
University Of Chile
Curated by ChEMBL
Affinity DataKi: 1.20nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR overexpressed in human SHEP cells after 75 mins by liquid scintillation spectrometric analy...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Centro De InvestigacióN Grupo Ferrer
Curated by ChEMBL
Centro De InvestigacióN Grupo Ferrer
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Binding affinity measured at the sigma receptor by the inhibition of [3H]-3-PPP binding to guinea pig cerebellum using unlabeled 3-PPP for nonspecifi...More data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 1.70nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Centro De InvestigacióN Grupo Ferrer
Curated by ChEMBL
Centro De InvestigacióN Grupo Ferrer
Curated by ChEMBL
Affinity DataKi: 1.90nMAssay Description:Binding affinity measured at the 5-hydroxytryptamine 2A receptor by the inhibition of [3H]-ketanserin binding to rat cortex using unlabeled mianserin...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Binding affinity towards muscarinic m1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesiense rhodesain expressed in Pichia pastoris using Cbz-Phe-Arg-AMC as substrate after 30 min by fl...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(RAT)
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Tested for its binding affinity towards sigma-1 site in rat brain, using [3H]DTG as radioligandMore data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 2.10nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Inhibition of human cathepsin L using Cbz-Phe-Arg-AMC as substrate after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Centro De InvestigacióN Grupo Ferrer
Curated by ChEMBL
Centro De InvestigacióN Grupo Ferrer
Curated by ChEMBL
Affinity DataKi: 2.40nMAssay Description:Binding affinity measured at the Alpha-1A adrenergic receptor by the inhibition of [3H]-prazosin binding to rat cortex using unlabeled WB-4101 for no...More data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 2.60nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 3.20nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 3.20nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 3.20nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
Affinity DataKi: 3.5nMAssay Description:Inhibition of human cathepsin L using Cbz-Phe-Arg-AMC as substrate after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.60nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesiense rhodesain expressed in Pichia pastoris using Cbz-Phe-Arg-AMC as substrate after 30 min by fl...More data for this Ligand-Target Pair
Affinity DataKi: 3.90nMAssay Description:Inhibition of Carica papaya papain by microtiter plate spectrofluorimetryMore data for this Ligand-Target Pair
TargetD(4) dopamine receptor(Homo sapiens (Human))
Centro De InvestigacióN Grupo Ferrer
Curated by ChEMBL
Centro De InvestigacióN Grupo Ferrer
Curated by ChEMBL
Affinity DataKi: 4.30nMAssay Description:Binding affinity measured at the Dopamine receptor D4 by the inhibition of [3H]-spiperone binding to human recombinant CHO cells using unlabeled halo...More data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 4.40nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
Affinity DataKi: 4.5nMAssay Description:Mixed noncompetitive inhibition of recombinant human N-terminal His-tagged KHKC expressed in Escherichia coli BL21 (DE3) using fructose as substrate ...More data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesiense rhodesain expressed in Pichia pastoris using Cbz-Phe-Arg-AMC as substrate after 30 min by fl...More data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 5.20nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Homo sapiens (Human))
Centro De InvestigacióN Grupo Ferrer
Curated by ChEMBL
Centro De InvestigacióN Grupo Ferrer
Curated by ChEMBL
Affinity DataKi: 5.40nMAssay Description:Binding affinity measured at the Dopamine receptor D3 by the inhibition of [3H]-YM-09151-2 binding to human recombinant CCL 1.3 cells using unlabeled...More data for this Ligand-Target Pair
TargetD(4) dopamine receptor(Homo sapiens (Human))
Centro De InvestigacióN Grupo Ferrer
Curated by ChEMBL
Centro De InvestigacióN Grupo Ferrer
Curated by ChEMBL
Affinity DataKi: 6.20nMAssay Description:Binding affinity measured at the Dopamine receptor D4 by the inhibition of [3H]-spiperone binding to human recombinant CHO cells using unlabeled halo...More data for this Ligand-Target Pair
Affinity DataKi: 6.30nMAssay Description:Inhibition of Carica papaya papain by microtiter plate spectrofluorimetryMore data for this Ligand-Target Pair
Affinity DataKi: 7.20nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesiense rhodesain expressed in Pichia pastoris using Cbz-Phe-Arg-AMC as substrate after 30 min by fl...More data for this Ligand-Target Pair
Affinity DataKi: 7.5nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesiense rhodesain expressed in Pichia pastoris using Cbz-Phe-Arg-AMC as substrate after 30 min by fl...More data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 8nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
University Of Chile
Curated by ChEMBL
University Of Chile
Curated by ChEMBL
Affinity DataKi: 8.10nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR overexpressed in human SHEP cells after 75 mins by liquid scintillation spectrometric analy...More data for this Ligand-Target Pair
Affinity DataKi: 8.20nMAssay Description:Inhibition of Carica papaya papain by microtiter plate spectrofluorimetryMore data for this Ligand-Target Pair
Affinity DataKi: 9.10nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesiense rhodesain expressed in Pichia pastoris using Cbz-Phe-Arg-AMC as substrate after 30 min by fl...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Centro De InvestigacióN Grupo Ferrer
Curated by ChEMBL
Centro De InvestigacióN Grupo Ferrer
Curated by ChEMBL
Affinity DataKi: 9.40nMAssay Description:Binding affinity measured at the 5-hydroxytryptamine 2A receptor by the inhibition of [3H]-ketanserin binding to rat cortex using unlabeled mianserin...More data for this Ligand-Target Pair