BindingDB PrimarySearch_ki

Found 833 with Last Name = 'he' and Initial = 'gw'

HIV-1 protease(Human immunodeficiency virus)
State University of New York

PNG

BDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)

Ki: 0.370nMAssay Description:Enzyme inhibition assay for silanediols, carbinols, and indinavir using assay system C.More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar

ChEBI
CHEMBL MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

HIV-1 protease(Human immunodeficiency virus)
State University of New York

PNG

BDBM40773(Silanediol, 17b)

Ki: 2.70nMAssay Description:Enzyme inhibition assay for silanediols, carbinols, and indinavir using assay system C.More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar

Details Article PubMed

HIV-1 protease(Human immunodeficiency virus)
State University of New York

PNG

BDBM40774(Carbinol, 18b)

Ki: 3.80nMAssay Description:Enzyme inhibition assay for silanediols, carbinols, and indinavir using assay system C.More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar

PC cid PC sid Similars

Details Article PubMed

Prothrombin(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50112086(3-({2-[(4-Carbamimidoyl-phenylamino)-methyl]-1-met...)

Ki: 4.5nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed

Prothrombin(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50432209(BIBR-1048 | BIBR-1048-BS-RS1 | DABIGATRAN ETEXILAT...)

Ki: 4.5nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Purchase DrugBank PC cid PC sid Similars

Details Article PubMed

HIV-1 protease(Human immunodeficiency virus)
State University of New York

PNG

BDBM40775(Carbinol, 18a)

Ki: 3.20E+3nMAssay Description:Enzyme inhibition assay for silanediols, carbinols, and indinavir using assay system C.More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar

PC cid PC sid Similars

Details Article PubMed

HIV-1 protease(Human immunodeficiency virus)
State University of New York

PNG

BDBM40772(Silanediol, 17a)

Ki: 3.20E+3nMAssay Description:Enzyme inhibition assay for silanediols, carbinols, and indinavir using assay system C.More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar

Details Article PubMed

Tyrosine-protein kinase JAK2(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL

PNG

BDBM50557389(CHEMBL4788363)

IC50: <0.0500nMAssay Description:Inhibition of human JAK2 by radiometric assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Tyrosine-protein kinase JAK2(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL

PNG

BDBM50557388(CHEMBL4743499)

IC50: 0.0990nMAssay Description:Inhibition of human JAK2 by radiometric assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Tyrosine-protein kinase JAK2(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL

PNG

BDBM50557390(CHEMBL4753959)

IC50: 0.130nMAssay Description:Inhibition of human JAK2 by radiometric assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Tyrosine-protein kinase JAK2(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL

PNG

BDBM50557387(CHEMBL4750568)

IC50: 0.150nMAssay Description:Inhibition of human JAK2 by radiometric assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Tyrosine-protein kinase JAK2(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL

PNG

BDBM50557391(CHEMBL4745155)

IC50: 0.260nMAssay Description:Inhibition of human JAK2 by radiometric assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Tyrosine-protein kinase JAK2(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL

PNG

BDBM50021656(BARICITINIB | INCB-028050 | LY-3009104 | US1011290...)

IC50: 0.290nMAssay Description:Inhibition of human JAK2 by radiometric assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase MCE
PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Tyrosine-protein kinase JAK2(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL

PNG

BDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)

IC50: 0.400nMAssay Description:Inhibition of human JAK2 by radiometric assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL

PNG

BDBM328998(1137478-52-4 | US11787792, Compound Y-158 | US9663...)

IC50: 0.5nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL

PNG

BDBM50555401(CHEMBL4742233)

IC50: 0.5nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL

PNG

BDBM50555385(CHEMBL4753307)

IC50: 0.5nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

RAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL

PNG

BDBM50307954(4-((4-Chlorobenzyloxy)methyl)-1-(7H-pyrrolo[2,3-d]...)

IC50: 0.590nMAssay Description:Inhibition of PKB in human U87MG cells assessed as GSK3beta phosphorylation by ELISAMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid Patents

Details Article PubMed

RAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL

PNG

BDBM50237622(4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4...)

IC50: 0.660nMAssay Description:Inhibition of PKB in human U87MG cells assessed as GSK3beta phosphorylation by ELISAMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Purchase CHEMBL MCE
MMDB PC cid PC sid Patents Similars

Details Article PubMed

Tyrosine-protein kinase JAK2(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL

PNG

BDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)

IC50: 0.75nMAssay Description:Inhibition of human JAK2 by radiometric assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL MCE
MMDB PC cid PC sid PDB Patents

Details Article PubMed PDB

3D Structure (crystal)

Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL

PNG

BDBM50555402(CHEMBL4790962)

IC50: 0.900nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Tyrosine-protein kinase JAK2(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL

PNG

BDBM433323(US10561657, Ruxolitinib | US10617692, Ruxolitinib ...)

IC50: 0.920nMAssay Description:Inhibition of human JAK2 by radiometric assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL

PNG

BDBM50401629(CHEMBL2203839)

IC50: <1nMAssay Description:Inhibition of CHK1 using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH as substrate after 1 hr by microfluidic assay in presence of ATPMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL

PNG

BDBM50401628(CHEMBL2203840)

IC50: <1nMAssay Description:Inhibition of CHK1 using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH as substrate after 1 hr by microfluidic assay in presence of ATPMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL

PNG

BDBM50555384(CHEMBL4789854)

IC50: 1nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

C-X-C chemokine receptor type 4(Homo sapiens (Human))
Anormed

Curated by ChEMBL

PNG

BDBM50369468(CHEMBL1202231)

IC50: 1nMAssay Description:Inhibitory activity against CX3C chemokine receptor 4-specific monoclonal antibody 12G5 (mAb-12G5) binding to human chemokinin receptor CXCR4 in lymp...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL

PNG

BDBM50401627(CHEMBL2203844)

IC50: <1nMAssay Description:Inhibition of CHK1 using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH as substrate after 1 hr by microfluidic assay in presence of ATPMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL

PNG

BDBM328993(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)

IC50: 1.30nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL

PNG

BDBM50555409(CHEMBL4754960)

IC50: 1.90nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

RAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL

PNG

BDBM50307955(4-(2,4-Dichlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimid...)

IC50: 1.90nMAssay Description:Inhibition of PKB in human PC3M cells assessed as GSK3beta phosphorylation by ELISAMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid Patents Similars

Details Article PubMed

Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL

PNG

BDBM50555405(CHEMBL4784718)

IC50: 2.10nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL

PNG

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

IC50: 2.10nMAssay Description:Competitive inhibition of human CHK1 using ATP as substrate by DELFIAMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL

PNG

BDBM328996(1137477-07-6 | US11787792, Compound Y-081 | US9663...)

IC50: 2.20nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

RAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL

PNG

BDBM50307942(4-Amino-N-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyr...)

IC50: 2.20nMAssay Description:Inhibition of PKBbeta by radiometric filter binding assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL

PNG

BDBM329000(1137478-46-6 | US11787792, Compound Y-153 | US9663...)

IC50: 2.20nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL

PNG

BDBM50555383(CHEMBL4784549)

IC50: 2.90nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Tyrosine-protein kinase JAK2(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL

PNG

BDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)

IC50: 2.90nMAssay Description:Inhibition of human JAK2 by radiometric assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL

PNG

BDBM50401632(CHEMBL2204590)

IC50: 2.90nMAssay Description:Inhibition of CHK1 using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH as substrate after 1 hr by microfluidic assay in presence of ATPMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

RAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL

PNG

BDBM50237622(4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4...)

IC50: 3nMAssay Description:Inhibition of PKB in human PC3M cells assessed as GSK3beta phosphorylation by ELISAMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Purchase CHEMBL MCE
MMDB PC cid PC sid Patents Similars

Details Article PubMed

Serine/threonine-protein kinase Chk2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL

PNG

BDBM50335684(4-FLUORO-2-(4-{[(3S,4R)-4-(1-HYDROXY-1-METHYLETHYL...)

IC50: 3nMAssay Description:Inhibition of CHK2 by DELFIA assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase CHEMBL MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed MMDB
PDB

3D Structure (crystal)

RAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL

PNG

BDBM50376061(CHEMBL409503)

IC50: 3nMAssay Description:Inhibition of PKBbeta recombinant by radiometric filter binding assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL

PNG

BDBM50401617(CHEMBL2204592 | US9403797, PAPC-A-02)

IC50: 3.10nMAssay Description:Inhibition of CHK1 using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH as substrate after 1 hr by microfluidic assay in presence of ATPMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL

PNG

BDBM328997(1137478-45-5 | US11787792, Compound Y-152 | US9663...)

IC50: 3.20nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL

PNG

BDBM50401615(CHEMBL2203842)

IC50: 3.40nMAssay Description:Inhibition of CHK1 using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH as substrate after 1 hr by microfluidic assay in presence of ATPMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Tyrosine-protein kinase JAK2(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL

PNG

BDBM50557395(CHEMBL4762807)

IC50: 3.60nMAssay Description:Inhibition of human JAK2 by radiometric assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

RAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL

PNG

BDBM50307956(4-Amino-N-(2,4-dichlorobenzyl)-1-(7H-pyrrolo[2,3-d...)

IC50: 3.80nMAssay Description:Inhibition of PKB in human PC3M cells assessed as GSK3beta phosphorylation by ELISAMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid Patents Similars

Details Article PubMed

Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL

PNG

BDBM50359810(CHEMBL1928701)

IC50: 3.80nMAssay Description:Competitive inhibition of human CHK1 using ATP as substrate by DELFIAMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid Patents Similars

Details Article PubMed

RAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL

PNG

BDBM50307957(4-Amino-N-(4-chloro-2-fluorobenzyl)-1-(7H-pyrrolo[...)

IC50: 4nMAssay Description:Inhibition of PKBbeta by radiometric filter binding assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid Patents Similars

Details Article PubMed

RAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL

PNG

BDBM50307975(4-Amino-N-(4-chlorobenzyl)-N-methyl-1-(7H-pyrrolo[...)

IC50: 4.20nMAssay Description:Inhibition of PKB in human PC3M cells assessed as GSK3beta phosphorylation by ELISAMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid Patents Similars

Details Article PubMed

Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL

PNG

BDBM50401616(CHEMBL2203841)

IC50: 4.40nMAssay Description:Inhibition of CHK1 using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH as substrate after 1 hr by microfluidic assay in presence of ATPMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Displayed 1 to 50 (of 833 total ) | Next | Last >>

Filter my 833 hits

Targets 46▿
- Serine/threonine-protein kinase Chk1 248
- RAC-beta serine/threonine-protein kinase 113
- Serine/threonine-protein kinase Chk2 94
- Serine/threonine-protein kinase Nek2 86
- Potassium voltage-gated channel subfamily H member 2 26
- Glycogen synthase kinase-3 beta 25
- Serine/threonine-protein kinase PLK1 24
- Histone acetyltransferase KAT2B 21
- cAMP-dependent protein kinase catalytic subunit alpha 19
- ATP-dependent molecular chaperone HSP82 18
- Tyrosine-protein kinase JAK2 16
- C-X-C chemokine receptor type 4 10
- Cyclin-dependent kinase 1 10
- Caspase-3 10
- Cytochrome P450 1A2 9
- Cytochrome P450 2C9 9
- Cytochrome P450 2C19 9
- Cytochrome P450 2D6 9
- Cytochrome P450 3A4 9
- RAC-alpha serine/threonine-protein kinase 9
- Histone acetyltransferase p300 7
- Cytochrome P450 2A6 6
- HIV-1 protease 5
- Cyclin-dependent kinase 2 4
- Dual specificity protein kinase TTK 4
- Tyrosine-protein kinase ABL1 4
- Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 4
- Aurora kinase A 4
- Serine/threonine-protein kinase Nek1 3
- Prothrombin 2
- Tyrosine-protein kinase Lck 1
- Serine/threonine-protein kinase D2 1
- Inward rectifier potassium channel 2 1
- Potassium voltage-gated channel subfamily A member 5 1
- Potassium voltage-gated channel subfamily D member 3 1
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 1
- Tyrosine-protein kinase Fyn 1
- Tyrosine-protein kinase Lyn 1
- Sodium channel protein type 5 subunit alpha 1
- Caspase-7 1
- Ribosomal protein S6 kinase beta-1 1
- Potassium voltage-gated channel subfamily KQT member 1 1
- Cytochrome P450 2E1 1
- Hepatocyte growth factor receptor 1
- Proto-oncogene tyrosine-protein kinase Src 1
- Voltage-dependent L-type calcium channel subunit alpha-1C 1
- ...
Publications 21▿
- J Med Chem 59: 5221-37 (2016) 138
- J Med Chem 54: 580-90 (2011) 72
- J Med Chem 55: 10229-40 (2012) 69
- J Med Chem 53: 2239-49 (2010) 67
- J Med Chem 54: 8328-42 (2011) 65
- J Med Chem 51: 2147-57 (2008) 57
- J Med Chem 53: 7682-98 (2010) 56
- J Med Chem 55: 3228-41 (2012) 52
- Bioorg Med Chem Lett 20: 4045-9 (2010) 46
- Bioorg Med Chem 14: 1255-73 (2006) 43
- J Med Chem 52: 4810-9 (2009) 30
- J Med Chem 54: 1626-39 (2011) 29
- Bioorg Med Chem 17: 467-74 (2009) 28
- J Med Chem 50: 2289-92 (2007) 19
- Bioorg Med Chem Lett 15: 3338-43 (2005) 18
- J Med Chem 64: 2228-2241 (2021) 16
- Nat Chem Biol 2: 543-50 (2006) 11
- J Med Chem 42: 3971-81 (1999) 10
- Chem Biol 8: 1161-6 (2001) 5
- Bioorg Med Chem Lett 23: 2089-92 (2013) 1
- Eur J Med Chem 57: 21-8 (2012) 1
Institutions 10▿
- The Institute Of Cancer Research 559
- Sareum 138
- Uk Centre For Cancer Therapeutics 43
- The Institute of Cancer Research 30
- Astex 19
- Moffitt Cancer Center 16
- University of Illinois 11
- Anormed 10
- State University of New York 5
- China Pharmaceutical University 2
Affinity: 0.050 to 2.1E+5 nM▿
- Ki 7
- IC50 797
- EC50 12
- Affinity ≤ nM
Xtal structures: 61
Docked structures: 56
Catalog Cmpds: 72