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Found 57 with Last Name = 'henson' and Initial = 'k'
TargetBeta-1 adrenergic receptor(Rattus norvegicus (Rat))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50352113(CHEMBL1824263)
Affinity DataKi:  77nMAssay Description:Displacement of [3H]-CGP12177 from beta1-adrenergic receptor in rat heart membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50352111(CHEMBL1824265)
Affinity DataKi:  2.30E+3nMAssay Description:Displacement of [125I]-Iodopindolol from beta1-adrenergic receptor after 1.5 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50352110(CHEMBL1824264)
Affinity DataKi:  2.40E+3nMAssay Description:Displacement of [125I]-Iodopindolol from beta1-adrenergic receptor after 1.5 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50352112(CHEMBL1824266)
Affinity DataKi:  3.00E+3nMAssay Description:Displacement of [125I]-Iodopindolol from beta1-adrenergic receptor after 1.5 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50352110(CHEMBL1824264)
Affinity DataKi:  5.50E+3nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor after 1.5 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50352110(CHEMBL1824264)
Affinity DataKi:  7.70E+3nMAssay Description:Displacement of [125I]-Iodopindolol from beta2-adrenergic receptor after 1.5 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50352111(CHEMBL1824265)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]-Iodopindolol from beta2-adrenergic receptor after 1.5 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50352112(CHEMBL1824266)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor after 1.5 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50352111(CHEMBL1824265)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor after 1.5 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50352112(CHEMBL1824266)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]-Iodopindolol from beta2-adrenergic receptor after 1.5 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM36336(CID24762166 | Purfalcamine, 1)
Affinity DataIC50:  17nMpH: 7.5 T: 2°CAssay Description:The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM36340(4-{2-trans-(4-Amino-cyclohexylamino)-6-[4-(piperid...)
Affinity DataIC50:  28nMpH: 7.5 T: 2°CAssay Description:The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM36339(3-{2-trans-(4-Amino-cyclohexylamino)-6-[4-(piperid...)
Affinity DataIC50:  71nMpH: 7.5 T: 2°CAssay Description:The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM36347(CID24762177 | {4-[9-(3-Fluoro-phenyl)-2-trans-(4-h...)
Affinity DataIC50:  150nMpH: 7.5 T: 2°CAssay Description:The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  240nMpH: 7.5 T: 2°CAssay Description:The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM36341(CID24762171 | {4-[2-trans-(4-Amino-cyclohexylamino...)
Affinity DataIC50:  240nMpH: 7.5 T: 2°CAssay Description:The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM36338(CID24762168 | {4-[2-trans-(4-Amino-cyclohexylamino...)
Affinity DataIC50:  342nMpH: 7.5 T: 2°CAssay Description:The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM36345(CID24762175 | {4-[2-(3-Morpholin-4-yl-propylamino)...)
Affinity DataIC50:  430nMpH: 7.5 T: 2°CAssay Description:The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM36348((4-{9-(3-Chloro-phenyl)-2-[2-(3H-imidazol-4-yl)-et...)
Affinity DataIC50:  626nMpH: 7.5 T: 2°CAssay Description:The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM36343(CID24762173 | N2-trans-(4-Amino-cyclohexyl)-N6-(4-...)
Affinity DataIC50:  703nMpH: 7.5 T: 2°CAssay Description:The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50318672((1R,3S)-5'-Chloro-3-methyl-2,3,4,9-tetrahydrospiro...)
Affinity DataIC50:  1.51E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50318670((1R,3S)-5'-Chloro-6-fluoro-3-methyl-2,3,4,9-tetrah...)
Affinity DataIC50:  1.72E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM36342(CID24762172 | {4-[2-trans-(4-Amino-cyclohexylamino...)
Affinity DataIC50:  3.49E+3nMpH: 7.5 T: 2°CAssay Description:The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM36346(CID24762176 | {4-[9-Phenyl-2-(quinolin-3-ylamino)-...)
Affinity DataIC50:  3.85E+3nMpH: 7.5 T: 2°CAssay Description:The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM36337(CID24762167 | {4-[2-trans-(4-Amino-cyclohexylamino...)
Affinity DataIC50:  4.04E+3nMpH: 7.5 T: 2°CAssay Description:The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50318668((1R,3S)-5',7-Dichloro-3-methyl-2,3,4,9-tetrahydros...)
Affinity DataIC50:  4.11E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50318666((1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-2,3,4,9-te...)
Affinity DataIC50:  5.42E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM36344(CID24762174 | {3-[2-trans-(4-Amino-cyclohexylamino...)
Affinity DataIC50:  6.87E+3nMpH: 7.5 T: 2°CAssay Description:The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50318664((1R,3S)-5'-Chloro-6,7-difluoro-3-methyl-2,3,4,9-te...)
Affinity DataIC50:  7.35E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50318671((1S,3R)-5'-Chloro-3-methyl-2,3,4,9-tetrahydrospiro...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50318665((1S,3R)-5',7-Dichloro-6-fluoro-3-methyl-2,3,4,9-te...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50318667((1S,3R)-5',7-Dichloro-3-methyl-2,3,4,9-tetrahydros...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50318663((1S,3R)-5'-Chloro-6,7-difluoro-3-methyl-2,3,4,9-te...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50318669((1S,3R)-5'-Chloro-6-fluoro-3-methyl-2,3,4,9-tetrah...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50318670((1R,3S)-5'-Chloro-6-fluoro-3-methyl-2,3,4,9-tetrah...)
Affinity DataIC50: >3.00E+4nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50318672((1R,3S)-5'-Chloro-3-methyl-2,3,4,9-tetrahydrospiro...)
Affinity DataIC50: >3.00E+4nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50318668((1R,3S)-5',7-Dichloro-3-methyl-2,3,4,9-tetrahydros...)
Affinity DataIC50: >3.00E+4nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50318664((1R,3S)-5'-Chloro-6,7-difluoro-3-methyl-2,3,4,9-te...)
Affinity DataIC50: >3.00E+4nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50318673((1R,3S)-5'-Bromo-3-methyl-3,4,5,1'-tetrahydro-2H-s...)
Affinity DataIC50: >3.00E+4nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM36347(CID24762177 | {4-[9-(3-Fluoro-phenyl)-2-trans-(4-h...)
Affinity DataEC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:This parasite proliferation assay, a modification of published DNA intercalating fluorescent dye-based assay, was adapted to 384-well plate format an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50241366((S)-1-(isopropylamino)-3-(m-tolyloxy)propan-2-ol |...)
Affinity DataKd:  0.380nMAssay Description:Binding affinity to beta-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM36345(CID24762175 | {4-[2-(3-Morpholin-4-yl-propylamino)...)
Affinity DataEC50:  2.99E+3nMpH: 7.5 T: 2°CAssay Description:This parasite proliferation assay, a modification of published DNA intercalating fluorescent dye-based assay, was adapted to 384-well plate format an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM36344(CID24762174 | {3-[2-trans-(4-Amino-cyclohexylamino...)
Affinity DataEC50:  1.30E+3nMpH: 7.5 T: 2°CAssay Description:This parasite proliferation assay, a modification of published DNA intercalating fluorescent dye-based assay, was adapted to 384-well plate format an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM36343(CID24762173 | N2-trans-(4-Amino-cyclohexyl)-N6-(4-...)
Affinity DataEC50:  174nMpH: 7.5 T: 2°CAssay Description:This parasite proliferation assay, a modification of published DNA intercalating fluorescent dye-based assay, was adapted to 384-well plate format an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM36342(CID24762172 | {4-[2-trans-(4-Amino-cyclohexylamino...)
Affinity DataEC50:  596nMpH: 7.5 T: 2°CAssay Description:This parasite proliferation assay, a modification of published DNA intercalating fluorescent dye-based assay, was adapted to 384-well plate format an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM36341(CID24762171 | {4-[2-trans-(4-Amino-cyclohexylamino...)
Affinity DataEC50:  535nMpH: 7.5 T: 2°CAssay Description:This parasite proliferation assay, a modification of published DNA intercalating fluorescent dye-based assay, was adapted to 384-well plate format an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM36340(4-{2-trans-(4-Amino-cyclohexylamino)-6-[4-(piperid...)
Affinity DataEC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:This parasite proliferation assay, a modification of published DNA intercalating fluorescent dye-based assay, was adapted to 384-well plate format an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM36339(3-{2-trans-(4-Amino-cyclohexylamino)-6-[4-(piperid...)
Affinity DataEC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:This parasite proliferation assay, a modification of published DNA intercalating fluorescent dye-based assay, was adapted to 384-well plate format an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM36338(CID24762168 | {4-[2-trans-(4-Amino-cyclohexylamino...)
Affinity DataEC50:  400nMpH: 7.5 T: 2°CAssay Description:This parasite proliferation assay, a modification of published DNA intercalating fluorescent dye-based assay, was adapted to 384-well plate format an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
The Scripps Research Institute

LigandPNGBDBM36337(CID24762167 | {4-[2-trans-(4-Amino-cyclohexylamino...)
Affinity DataEC50:  312nMpH: 7.5 T: 2°CAssay Description:This parasite proliferation assay, a modification of published DNA intercalating fluorescent dye-based assay, was adapted to 384-well plate format an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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